| Identification | Back Directory | [Name]
CC-90009 | [CAS]
1860875-51-9 | [Synonyms]
CC-90009
1860875-51-9
Cereblon modulator 1
Cereblon modulator 1（CC-99）
CC-90009; CC 90009; CC90009;
Benzeneacetamide, 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro- | [Molecular Formula]
C22H18ClF2N3O4 | [MDL Number]
MFCD32690104 | [MOL File]
1860875-51-9.mol | [Molecular Weight]
461.85 |
| Chemical Properties | Back Directory | [Boiling point ]
770.1±60.0 °C(Predicted) | [density ]
1.466±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (541.30 mM) | [form ]
A crystalline solid | [pka]
10.66±0.40(Predicted) | [color ]
Off-white to light yellow | [InChIKey]
PWBHUSLMHZLGRN-UHFFFAOYSA-N | [SMILES]
O=C1C2=CC=C(CNC(=O)C(C3C=CC(Cl)=CC=3)(F)F)C=C2CN1C1CCC(=O)NC1=O |
| Hazard Information | Back Directory | [Uses]
Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation[1][2]. | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Christine Surka, et al. CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells. Blood. 2021 Feb 4;137(5):661-677. DOI:10.1182/blood.2020008676
[2] Joshua D Hansen, et al. CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2021 Feb 25;64(4):1835-1843. DOI:10.1021/acs.jmedchem.0c01489 |
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