| Identification | Back Directory | [Name]
3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE | [CAS]
186611-55-2 | [Synonyms]
SU 4313
SU4313 SU-4313 SU 4313
3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE
2H-Indol-2-one,1,3-dihydro-3-[[4-(1-methylethyl)phenyl]methylene]- | [Molecular Formula]
C18H17NO | [MDL Number]
MFCD00118155 | [MOL File]
186611-55-2.mol | [Molecular Weight]
263.33 |
| Chemical Properties | Back Directory | [Boiling point ]
456.001±45.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.150±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Yellow crystals. | [pka]
12.982±0.20(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC50s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation[1]. | [IC 50]
PDGFR: 14.5 μM (IC50); FLK-1: 18.8 μM (IC50); EGFR: 11 μM (IC50); HER2: 16.9 μM (IC50); IGF-1R: 8.0 μM (IC50) | [References]
[1] Peng Cho Tang, et al. Indolinone compounds for the treatment of disease. WO1996040116A1. |
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