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186611-55-2

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186611-55-2 Structure

186611-55-2 Structure
IdentificationBack Directory
[Name]

3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE
[CAS]

186611-55-2
[Synonyms]

SU 4313
SU4313 SU-4313 SU 4313
3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE
2H-Indol-2-one,1,3-dihydro-3-[[4-(1-methylethyl)phenyl]methylene]-
[Molecular Formula]

C18H17NO
[MDL Number]

MFCD00118155
[MOL File]

186611-55-2.mol
[Molecular Weight]

263.33
Chemical PropertiesBack Directory
[Boiling point ]

456.001±45.00 °C(Press: 760.00 Torr)(predicted)
[density ]

1.150±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ]

Yellow crystals.
[pka]

12.982±0.20(predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC50s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation[1].
[IC 50]

PDGFR: 14.5 μM (IC50); FLK-1: 18.8 μM (IC50); EGFR: 11 μM (IC50); HER2: 16.9 μM (IC50); IGF-1R: 8.0 μM (IC50)
[References]

[1] Peng Cho Tang, et al. Indolinone compounds for the treatment of disease. WO1996040116A1.
Spectrum DetailBack Directory
[Spectrum Detail]

3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE(186611-55-2)1HNMR
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