| Identification | Back Directory | [Name]
SU 5205 | [CAS]
3476-86-6 | [Synonyms]
SU 5205
SU 5205; SU-5205; SU5205
2H-Indol-2-one, 3-[(4-fluorophenyl)methylene]-1,3-dihydro- | [Molecular Formula]
C15H10FNO | [MOL File]
3476-86-6.mol | [Molecular Weight]
239.24 |
| Chemical Properties | Back Directory | [Melting point ]
194-196 °C | [Boiling point ]
435.3±45.0 °C(Predicted) | [density ]
1.306±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
12.69±0.20(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
SU5205 is an inhibitor of VEGFR2 (FLK-1), with an IC50 of 9.6 μM[1]. | [Biological Activity]
SU5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 9.6 μM. | [Synthesis]
GENERAL STEPS: 2-Indolone (1 eq.) and p-fluorobenzaldehyde (1 eq.) were added to ethanol (EtOH, 3 mL/0.2 mmol) and the mixture was stirred until completely dissolved. Subsequently piperidine (0.1 eq.) was added and the reaction mixture was heated to 90 °C and kept reacting for 3-7 hours. After completion of the reaction, it was cooled to room temperature. The resulting precipitate was collected by filtration, washed with cold ethanol and dried to give 3-(4-fluorophenylmethylene)indolin-2-one crude. If further purity is required, the product can be purified by ethanol recrystallization. | [in vitro]
SU5205 inhibits ligand-induced endothelial mitogenesis for VEGF with an IC 50 of 5.1 μM. | [target]
| Target | Value | VEGFR2
(Cell-free assay) | 9.6 μM |
| [IC 50]
Flk-1: 9.6 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Huh S, et al. Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis. Biol Pharm Bull. 2010;33(7):1242-5. DOI:10.1248/bpb.33.1242
[2] Torsten K, et, al. Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor. Bioorg Med Chem. 2009 Nov 15; 17(22): 7732-42. |
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| Company Name: |
Shaanxi Dideu Medichem Co. Ltd
|
| Telephone: |
+86-029-81138252 +86-173 9270 1263 |
| Website: |
https://www.chemicalbook.com/manufacturer/shaanxi-dideu-medichem-222/ |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|