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1873376-49-8

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1873376-49-8 Structure

1873376-49-8 Structure
IdentificationBack Directory
[Name]

CXCR2-IN-1
[CAS]

1873376-49-8
[Synonyms]

CXCR2-IN-1
CXCR2 inhibitor 1
N-(2-Chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]urea
Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-
[Molecular Formula]

C19H20Cl2FN3O4S
[MDL Number]

MFCD31382127
[MOL File]

1873376-49-8.mol
[Molecular Weight]

476.35
Chemical PropertiesBack Directory
[Boiling point ]

538.1±50.0 °C(Predicted)
[density ]

1.528±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 5.4 mg/mL (11.34 mM)
[form ]

Solid
[pka]

5.02±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

N-(2-Chloro-3-fluorophenyl)-N''-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]urea is a CNS penetrant CXCR2 antagonist.
[in vivo]

CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis[1].

[IC 50]

CXCR2: 9.3 (pIC50)
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

CXCR2-IN-1(1873376-49-8)1HNMR
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