| Identification | Back Directory | [Name]
CASPASE INHIBITOR3 | [CAS]
187389-53-3 | [Synonyms]
N-BOC-D-FMK
CASPASE INHIBITOR3
Boc-D-FMK/Boc-Asp(OMe)-fluoromethyl ketone
Boc-D-FMK - Boc-Asp(OMe)-fluoromethyl ketone | BAF
N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone
(S)-methyl 3-((tert-butoxycarbonyl)amino)-5-fluoro-4-oxopentanoate
(3S)-3-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid methyl ester
Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester, (3S)- | [Molecular Formula]
C11H18FNO5 | [MDL Number]
MFCD07370667 | [MOL File]
187389-53-3.mol | [Molecular Weight]
263.26 |
| Chemical Properties | Back Directory | [Boiling point ]
383.5±37.0 °C(Predicted) | [density ]
1.150±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
-20°C | [solubility ]
Soluble in dry DMSO or DMF at approximately 20mM. Store stock solutions at -20°C. | [form ]
Powder | [pka]
10.12±0.46(Predicted) | [color ]
Off-white | [InChI]
InChI=1S/C11H18FNO5/c1-11(2,3)18-10(16)13-7(8(14)6-12)5-9(15)17-4/h7H,5-6H2,1-4H3,(H,13,16)/t7-/m0/s1 | [InChIKey]
MXOOUCRHWJYCAL-ZETCQYMHSA-N | [SMILES]
C(OC)(=O)C[C@H](NC(OC(C)(C)C)=O)C(=O)CF |
| Hazard Information | Back Directory | [Uses]
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) has been used as a caspase inhibitor to study its effects on lactate dehydrogenase (LDH) leakage, apoptosis and virus proliferation in chorion cells , as a component of the transplantation medium for the transplantation of human embryonic stem cells (ESC)-derived medial ganglionic eminence (MGE) cells into hippocampus of mice , as a protease inhibitor to study its effects on cell death in parasites . | [Uses]
N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone is used as a novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology and irreversibly binds to activated caspases to block apoptosis. It is useful for in vitro and in vivo applications. | [Biochem/physiol Actions]
Boc-Asp(OMe)-fluoromethyl ketone (Boc-D-fmk) permits cell permeability. It is a caspase inhibitor and suppresses apoptosis induced by various kinds of stimuli. Boc-D-fmk poorly inhibits caspases-2, -5, -6 and -10. | [IC 50]
Caspase |
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| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|