| Identification | Back Directory | [Name]
3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenyl-1-piperidinyl]methyl]-1,2-dihydro-, rel- | [CAS]
187724-85-2 | [Synonyms]
L741671
L-741671
L 741671
3H-1,2,4-Triazol-3-one, 5-[[(2R,3R)-3-[[3,5-bis(trifluoromethyl)phenyl]methoxy]-2-phenyl-1-piperidinyl]methyl]-1,2-dihydro-, rel- | [Molecular Formula]
C23H22F6N4O2 | [MOL File]
187724-85-2.mol | [Molecular Weight]
500.44 |
| Hazard Information | Back Directory | [Uses]
L-741671 is a selective and brain-permeable antagonist of neurokininl (hNKI) receptor, with Kis of 64 nM, 0.03 nM and 0.7 nM in rat, human and ferret, respectively[1]. | [IC 50]
hNK1: 0.03 nM (Ki) | [References]
[1] F D Tattersall, et al. Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 1996;35(8):1121-9. DOI:10.1016/s0028-3908(96)00020-2 |
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