| Identification | Back Directory | [Name]
ZLN-024 hydrochloride | [CAS]
1883548-91-1 | [Synonyms]
ZLN024 hydrochloride
ZLN-024 hydrochloride | [Molecular Formula]
C??H??BrClN?OS | [MDL Number]
MFCD28166492 | [MOL File]
1883548-91-1.mol | [Molecular Weight]
361.68 |
| Hazard Information | Back Directory | [Uses]
ZLN 024 Hydrochloride acts as an allosteric AMP-activated protein kinase activator, stimulating glucose uptake and fatty acid oxidation. Improved glucose tolerance and cholesterol content. | [in vivo]
C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. During the treatment period, there is no significant alteration in food intake and body weight compared with the vehicle group. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased[1]. | [IC 50]
AMPK α2β2γ1: 0.13 μM (EC50); AMPK α1β1γ1: 0.42 μM (EC50); AMPK α2β1γ1: 0.95 μM (EC50) | [storage]
Store at +4°C |
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