| Identification | Back Directory | [Name]
ZLN-024 | [CAS]
723249-01-2 | [Synonyms]
ZLN024
ZLN-024
2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]-pyrimidine
2-[2-(2-bromo-4-methylphenoxy)ethylsulfanyl]pyrimidine
Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]- | [Molecular Formula]
C13H13BrN2OS | [MDL Number]
MFCD05155678 | [MOL File]
723249-01-2.mol | [Molecular Weight]
325.22 |
| Chemical Properties | Back Directory | [Boiling point ]
443.3±35.0 °C(Predicted) | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [pka]
0.12±0.33(Predicted) | [color ]
white to beige | [InChI]
1S/C13H13BrN2OS/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13/h2-6,9H,7-8H2,1H3 | [InChIKey]
KWJRSHZSULRJHE-UHFFFAOYSA-N | [SMILES]
S(CCOc2c(cc(cc2)C)Br)c1ncccn1 |
| Hazard Information | Back Directory | [Uses]
ZLN024 is a useful chemical reagent. | [Biological Activity]
ZLN024 is an allosteric activator of AMPK hetero-trimers. The compound ZLN024 protects against dephosphorylation of Thr172which is critical for activityand antagonizes AMPK autoinhibition. ZLM024 improves glucose tolerance and lowers total cholesterol levels in db/db mice. | [in vivo]
C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. During the treatment period, there is no significant alteration in food intake and body weight compared with the vehicle group. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased[1]. | [IC 50]
AMPK α2β2γ1: 0.13 μM (EC50); AMPK α1β1γ1: 0.42 μM (EC50); AMPK α2β1γ1: 0.95 μM (EC50) |
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Lynnchem
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86-(0)29-85992781 17792393971 |
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http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
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44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
| Company Name: |
Musechem
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+1-800-259-7612 |
| Website: |
www.musechem.com |
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