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723249-01-2

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723249-01-2 Structure

723249-01-2 Structure
IdentificationBack Directory
[Name]

ZLN-024
[CAS]

723249-01-2
[Synonyms]

ZLN024
ZLN-024
2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]-pyrimidine
2-[2-(2-bromo-4-methylphenoxy)ethylsulfanyl]pyrimidine
Pyrimidine, 2-[[2-(2-bromo-4-methylphenoxy)ethyl]thio]-
[Molecular Formula]

C13H13BrN2OS
[MDL Number]

MFCD05155678
[MOL File]

723249-01-2.mol
[Molecular Weight]

325.22
Chemical PropertiesBack Directory
[Boiling point ]

443.3±35.0 °C(Predicted)
[density ]

1.49±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: soluble20mg/mL, clear
[form ]

powder
[pka]

0.12±0.33(Predicted)
[color ]

white to beige
[InChI]

1S/C13H13BrN2OS/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13/h2-6,9H,7-8H2,1H3
[InChIKey]

KWJRSHZSULRJHE-UHFFFAOYSA-N
[SMILES]

S(CCOc2c(cc(cc2)C)Br)c1ncccn1
Safety DataBack Directory
[Symbol(GHS) ]

Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
[Signal word ]

Danger
[Hazard statements ]

H302-H315-H318-H335
[Precautionary statements ]

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
[Hazard Codes ]

Xn
[Risk Statements ]

22-37/38-41
[Safety Statements ]

26-39
[WGK Germany ]

3
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
Hazard InformationBack Directory
[Uses]

ZLN024 is a useful chemical reagent.
[Biological Activity]

ZLN024 is an allosteric activator of AMPK hetero-trimers. The compound ZLN024 protects against dephosphorylation of Thr172which is critical for activityand antagonizes AMPK autoinhibition. ZLM024 improves glucose tolerance and lowers total cholesterol levels in db/db mice.
[in vivo]

C57BKS db/db mice are administered a 15 mg/kg/day dose of ZLN024 by daily gavage for 5 weeks; 250 mg/kg/day Metformin (Met) is used as a positive control. During the treatment period, there is no significant alteration in food intake and body weight compared with the vehicle group. After 4 weeks of treatment, ZLN024 improves glucose tolerance. ZLN024 reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content are decreased[1].

[IC 50]

AMPK α2β2γ1: 0.13 μM (EC50); AMPK α1β1γ1: 0.42 μM (EC50); AMPK α2β1γ1: 0.95 μM (EC50)
Spectrum DetailBack Directory
[Spectrum Detail]

ZLN-024(723249-01-2)1HNMR
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