| Identification | Back Directory | [Name]
ISOXATHION | [CAS]
18854-01-8 | [Synonyms]
e-48
si-6711
KARPHOS
ISOXATHION
Isoxathion 0.1
ISOXATHION STANDARD
Isoxathion Solution, 100ppm
O,O-diethyl O-5-phenylisoxazol-3-ylphosphorothioate
o,o-diethylo-(5-phenyl-3-isoxazolyl)phosphorothioate
PHOSPHOROTHIOICACID,O,O-DIETHYLO-(5-PHENYL-3-ISOXAZOLYL)
o,o-diethylo-(3-(5-phenyl)-1,2-isoxazolyl)phosphorothionate
phosphorothioicacid,o,o-diethylo-(5-phenyl-3-isoxazolyl)ester
Thiophosphoric acid O,O-diethyl O-(5-phenyl-3-isoxazolyl) ester
isoxathion (ISO) O,O-diethyl O-5-phenylisoxazol-3-ylphosphorothioate | [EINECS(EC#)]
242-624-8 | [Molecular Formula]
C13H16NO4PS | [MDL Number]
MFCD00210313 | [MOL File]
18854-01-8.mol | [Molecular Weight]
313.31 |
| Chemical Properties | Back Directory | [Melting point ]
<25℃ | [Boiling point ]
160°C (rough estimate) | [density ]
1.48 g/ml | [vapor pressure ]
<1.3 x 10-4 Pa (25 °C) | [storage temp. ]
0-6°C
| [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
liquid | [pka]
-6.17±0.28(Predicted) | [Water Solubility ]
1.9 mg l-1 (25 °C) | [color ]
Colourless to Pale Yellow | [Specific Gravity]
1.48 | [BRN ]
1222135 | [EPA Substance Registry System]
Isoxathion (18854-01-8) |
| Hazard Information | Back Directory | [Definition]
ChEBI: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group is replaced by a 5-phenyl-1,2-oxazol-3-yl group. | [Description]
Isoxathion is a pale yellow liquid, bp 160 ?C/0.15 mm
Hg, vp <0.133mPa (25 ?C). Solubility in water is 1.9 mg/L
(25 ?C). It is readily soluble in most organic solvents. Log
Kow = 3.88. It is unstable to alkali. | [Uses]
Isoxathion is used as a pesticide. | [Uses]
Isoxathion is used to control sucking pests, leaf miners and some
chewing pests in a variety of fruit, vegetables and ornamental plants. | [Metabolic pathway]
The principal route of isoxathion metabolism in soil, plants and mammals
is by hydrolysis, probably via the oxon to 3-hydroxy-5-phenylisoxazole
which is rapidly conjugated in both plants and rats. In soils, and to a
lesser extent in plants and mammals, further metabolism of 3-hydroxy-
5-phenylisoxazole proceeds via opening of the isoxazole ring to give
various metabolites of which benzoic acid is one of the more important.
De-ethylation of the phosphate moiety has not been observed. | [Metabolism]
The principal degradation route of isoxathion in animals,
plants, and soil is cleavage of P?O-isoxazole through
oxidative desulfuration to the oxon followed by hydrolysis
to 3-hydroxy-5-phenylisoxazole, which is conjugated in
both plants and rats. | [Degradation]
Isoxathion is unstable to alkalis (PM). The hydrolysis product, 3-hydroxy-
5-phenylisoxazole (2), yielded 5-phenyl-3H-oxazolin-2-one (3) as the
major photoproduct via a photolytic rearrangement (Nakagawa et al.,1974). | [Toxicity evaluation]
The acute oral LD50 for rats is 112 mg/kg. NOEL
(2 yr) for rats is 1.2 mg/kg b.w. DT50 in soil is 9–40 d. |
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