| Identification | Back Directory | [Name]
2-HYDROXY-4-PYRIDINECARBOXALDEHYDE | [CAS]
188554-13-4 | [Synonyms]
2-AMINO-5-(AMINOMETH
2-HYDROXY-4-FORMYLPYRIDINE
2-Hydroxyisonicotinaldehyde
2-oxo-1H-pyridine-4-carbaldehyde
2-HYDROXY-PYRIDINE-4-CARBALDEHYDE
2-HYDROXYPYRIDINE-4-CARBOXALDEHYDE
2-HYDROXY-4-PYRIDINECARBOXALDEHYDE
2-AMINO-5-(AMINOMETHYL)-4-METHYLTHIAZOLE
2-Oxo-1,2-dihydro-pyridine-4-carbaldehyde
6-Oxo-1,6-dihydropyridine-4-carboxaldehyde
1,2-Dihydro-2-oxo-4-pyridinecarboxaldehyde
4-Pyridinecarboxaldehyde, 1,2-dihydro-2-oxo-
4-Pyridinecarboxaldehyde,1,2-dihydro-2-oxo-(9CI)
2-HYDROXY-4-PYRIDINECARBOXALDEHYDE ISO 9001：2015 REACH | [Molecular Formula]
C6H5NO2 | [MDL Number]
MFCD03788455 | [MOL File]
188554-13-4.mol | [Molecular Weight]
123.11 |
| Questions And Answer | Back Directory | [Synthesis]
Anhydrous dioxane (35 mL) was added to a mixture of 2-hydroxy-4-methylpyridine (2.10 g, 19.2 mmol) and selenium dioxide (2.50 g, 22.5 mmol). The heterogeneous solution was refluxed under argon for 48 hours. The mixture was cooled to room temperature. The mixture was treated with sodium bicarbonate (1.5 g). The mixture was stirred for 3 hours to neutralize acidic byproducts. The resulting dark brown suspension was filtered through a pad of magnesium sulfate (2.5 g), Florisic (2.5 g), and diatomaceous earth (2.5 g) to remove insoluble residues. The yellow filtrate was concentrated under vacuum to give the crude compound (1.40 g). The crude product was purified by silica gel column chromatography in ethyl acetate and 9:1 ethyl acetate/methanol to obtain 2-Hydroxy-4-pyridinecarboxaldehyde.  |
| Chemical Properties | Back Directory | [Melting point ]
79-81 °C | [Boiling point ]
333.7±42.0 °C(Predicted) | [density ]
1.365±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
solid | [pka]
11.17±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
2-Hydroxy-4-pyridinecarboxaldehyde is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
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Cool Pharm, Ltd
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021-60455363 18019463053 |
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www.coolpharm.com |
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NovoChemy Ltd.
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86-(0)21-31261262 373522135 |
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www.novochemy.com |
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