| Identification | More | [Name]
2-Chloro-6-methoxyisonicotinic acid | [CAS]
15855-06-8 | [Synonyms]
2-CHLORO-6-METHOXYISONICOTINIC ACID
2-CHLORO-6-METHOXYPYRIDINE-4-CARBOXYLIC ACID
BUTTPARK 43\57-34
TIMTEC-BB SBB005427
2-Chloro-6-methoxy-4-pyridinecarboxylic acid | [Molecular Formula]
C7H6ClNO3 | [MDL Number]
MFCD00173928 | [Molecular Weight]
187.58 | [MOL File]
15855-06-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
214 °C | [Boiling point ]
209-213℃ | [density ]
1.430±0.06 g/cm3(Predicted) | [storage temp. ]
Store at room temperature | [form ]
powder | [pka]
2.88±0.10(Predicted) | [color ]
White | [InChI]
1S/C7H6ClNO3/c1-12-6-3-4(7(10)11)2-5(8)9-6/h2-3H,1H3,(H,10,11) | [InChIKey]
PJQBTHQTVJMCFX-UHFFFAOYSA-N | [SMILES]
COc1cc(cc(Cl)n1)C(O)=O | [CAS DataBase Reference]
15855-06-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S37/39:Wear suitable gloves and eye/face protection .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2933399990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Synthesis]
a) 2,6-Dichloroisonicotinic acid (200 g, 1.04 mol) was dissolved in methanol (3 L) and 32% aqueous sodium hydroxide solution (770 mL) was added. The stirred mixture was heated to 34°C, then warmed to 70°C and kept at this temperature for 4 hours of reaction. After the reaction was completed, it was cooled to room temperature. The reaction mixture was neutralized with 32% aqueous hydrochloric acid solution (100 mL) and 25% aqueous hydrochloric acid solution (700 mL). The mixture was stirred at room temperature overnight. The white precipitate formed was collected by filtration, washed with methanol and dried. The filtrate was evaporated and the residue was suspended in water (200 mL). The resulting mixture was heated to 60 °C and the solid product was collected, washed with water and dried. All products were combined to give 2-chloro-6-methoxyisonicotinic acid (183 g) as a white solid; LC-MS: t R = 0.80 min, [M + 1] + = 187.93. | [References]
[1] Tetrahedron, 2002, vol. 58, # 34, p. 6951 - 6963
[2] Organic Letters, 2000, vol. 2, # 22, p. 3421 - 3423
[3] Patent: WO2011/7324, 2011, A1. Location in patent: Page/Page column 20
[4] Patent: US2012/108638, 2012, A1. Location in patent: Page/Page column 8
[5] Patent: US2013/303514, 2013, A1. Location in patent: Paragraph 0192 |
|
|