| Identification | Back Directory | [Name]
AMP 397 | [CAS]
188696-80-2 | [Synonyms]
AMP 397
BecaMpanel
Becampanel
(AMP 397)
Phosphonic acid, P-[[[(1,2,3,4-tetrahydro-7-nitro-2,3-dioxo-5-quinoxalinyl)methyl]amino]methyl]- | [Molecular Formula]
C10H11N4O7P | [MDL Number]
MFCD09970982 | [MOL File]
188696-80-2.mol | [Molecular Weight]
330.19 |
| Hazard Information | Back Directory | [Uses]
Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent. | [Biological Activity]
AMP 397 is a potent AMPA antagonist and an antiepileptic drug. | [in vitro]
AMP 397 is negative in a mouse lymphoma tk assay, which includes a 24 h treatment without S9. A weak micronucleus induction in vitro is found at the highest concentrations tested in V79 cells with S9. | [in vivo]
AMP 397 is negative in the following in vivo studies, which includes the maximum tolerated doses of 320 mg/kg in mice and 2000 mg/kg in rats. It has no genotoxic potential in vivo. < p> | [storage]
Store at -20°C | [References]
[1] Suter W, et al. Genotoxicity assessment of the antiepileptic drug AMP397, an Ames-positive aromatic nitro compound. Mutat Res. 2002 Jul 25;518(2):181-94. DOI:10.1016/s1383-5718(02)00105-5 |
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