| Identification | Back Directory | [Name]
HX 630 | [CAS]
188844-52-2 | [Synonyms]
HX 630
4-(7,8,9,10-tetrahydro-7,7,10,10-tetraMethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl)benzoic Acid
Benzoic acid, 4-(7,8,9,10-tetrahydro-7,7,10,10-tetramethylbenzo[b]naphtho[2,3-f][1,4]thiazepin-12-yl)- | [Molecular Formula]
C28H27NO2S | [MOL File]
188844-52-2.mol | [Molecular Weight]
441.58 |
| Hazard Information | Back Directory | [Uses]
A nuclear receptor retinoid X receptor (RXR) agonist that exerts antiproliferative effects in vascular smooth muscle cells (VSMCs) in vivo and in vitro. A potential therapeutic target for vascular injury and intimal thickening. It efficiently enhanced ABCA1 mRNA expression and apoA-I-dependent cellular cholesterol release in differentiated THP-1 cells. | [in vivo]
HX630 (5 mg/kg, intraperitoneal injection, 3 times a week for 3 weeks) can reduce tumor growth in BALB/c-nu mouse model infected with AtT20 cells[1] .
| Animal Model: | Female BALB/c-nu mice (nu/nu)?with AtT20 cells[1] | | Dosage: | 5 mg/kg | | Administration: | i.p., 3 times a week for 3 weeks | | Result: | Significantly reduced tumor volume and Pomc mRNA expression in tumor cells, but body weight and plasma ACTH levels were not significantly different. |
| [storage]
Store at -20°C |
|
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|