| Identification | Back Directory | [Name]
4-Quinolinamine, 2-(4-methoxyphenyl)-N-[3-(1-piperidinyl)propyl]- | [CAS]
1908414-42-5 | [Synonyms]
ML400
CID73050863
CID-73050863
CID 73050863
4-Quinolinamine, 2-(4-methoxyphenyl)-N-[3-(1-piperidinyl)propyl]- | [Molecular Formula]
C24H29N3O | [MOL File]
1908414-42-5.mol | [Molecular Weight]
375.51 |
| Hazard Information | Back Directory | [Description]
ML400 is an allosteric inhibitor of LMPTP. ML400. ML400 is potent (EC50～1μM), selective against other phosphatases, and displays good cell-based activity as well as rodent pharmacokinetics. As such it should be a valuable tool to explore the effects of selective LMPTP inhibition in vitro and in vivo. | [Uses]
ML 400 is a potent and selective LMPTP inhibitor with an IC50 value of 1680 nM. ML 400 inhibits adipogenesis[1]. | [References]
[1] Ardecky RJ, et al. Allosteric Small Molecule Inhibitors of LMPTP. 2014 Apr 15 [updated 2015 Jan 16]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID:25834896 |
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