| Identification | More | [Name]
1-BOC-2-METHYL-PIPERIDIN-4-ONE | [CAS]
190906-92-4 | [Synonyms]
1-BOC-2-METHYL-PIPERIDIN-4-ONE
1-N-BOC-2-METHYL-PIPERIDIN-4-ONE
1-TERT-BUTOXYCARBONYL-2-METHYL-4-PIPERIDONE
2-METHYL-4-OXOPIPERIDINE, N-BOC PROTECTED
TERT-BUTYL 2-METHYL-4-OXOPIPERIDINE-1-CARBOXYLATE
1-Boc-2-methyl-4-piperidinone
1-Boc-2-Methyl-Piperidinone
2-Methyl-4-oxopiperidine, N-BOC protected 97%
N-Boc-2-methyl-piperidone | [Molecular Formula]
C11H19NO3 | [MDL Number]
MFCD04035608 | [Molecular Weight]
213.27 | [MOL File]
190906-92-4.mol |
| Chemical Properties | Back Directory | [Boiling point ]
298.8±33.0 °C(Predicted) | [density ]
1.060±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
solid | [pka]
-1.52±0.40(Predicted) | [color ]
White to light yellow | [InChI]
InChI=1S/C11H19NO3/c1-8-7-9(13)5-6-12(8)10(14)15-11(2,3)4/h8H,5-7H2,1-4H3 | [InChIKey]
HQMYWQCBINPHBB-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC(=O)CC1C | [CAS DataBase Reference]
190906-92-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
1-Boc-2-methyl-piperidin-4-one s a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research. | [Synthesis]
1-tert-butoxycarbonyl-2-methyl-4-piperidone vinyl acetal (6.00 g) was used as starting material and dissolved in acetone (150 mL). To this solution, p-toluenesulfonic acid monohydrate (4.40 g) was slowly added under ice bath cooling and stirring conditions. After addition, the reaction mixture was gradually warmed to room temperature with continuous stirring overnight. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate and the organic layer was subsequently washed with saturated sodium bicarbonate solution and saturated aqueous sodium chloride solution sequentially. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent to afford 1-tert-butoxycarbonyl-2-methyl-piperidone (2.40 g, 48% yield) as a yellow oil. Its 1H NMR (500 MHz, CDCl3) data were as follows: δ 1.18 (3H, d, J=7.0 Hz), 1.49 (9H, s), 2.20-2.30 (1H, m), 2.30-2.40 (1H, m), 2.45-2.55 (1H, m), 2.65-2.70 (1H, m), 3.25-3.35 ( 1H, m), 3.90-4.05 (1H, m), 4.20-4.30 (1H, m). | [References]
[1] Patent: EP1375482, 2004, A1. Location in patent: Page 153 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Tetranov Biopharm
|
| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
|