| Identification | Back Directory | [Name]
NPGB | [CAS]
19135-17-2 | [Synonyms]
NPGB
PNPGB
Nsc163801
P-NITROPHENYL P'-GUANIDINOBENZOATE HCL
4-NITROPHENYL 4-GUANIDINOBENZOATE &
P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE
4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE
p-nitrophenyl-p'-guanidinobenzoateHClcrystalline
4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE
P'-GUANIDINOBENZOIC ACID P-NITROPHENYL ESTER HYDROCHLORIDE
p-Nitrophenyl-p'-guanidinobenzoatehydrochloridecrystalline
(4-nitrophenyl)4-(diaminomethylideneamino)benzoate,hydrochloride
4-nitrophenyl 4-[(aminoiminomethyl)amino]benzoate monohydrochloride
4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB
4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate
Benzoic acid, 4-(aminoiminomethyl)amino-, 4-nitrophenyl ester, monohydrochloride | [EINECS(EC#)]
242-831-3 | [Molecular Formula]
C14H13ClN4O4 | [MDL Number]
MFCD00037010 | [MOL File]
19135-17-2.mol | [Molecular Weight]
336.73 |
| Chemical Properties | Back Directory | [Melting point ]
241-243 °C | [storage temp. ]
-20°C | [solubility ]
formic acid: soluble 49.00-51.00mg/mL | [form ]
Solid | [color ]
White to off-white | [BRN ]
8024554 | [InChI]
1S/C14H12N4O4.ClH/c15-14(16)17-10-3-1-9(2-4-10)13(19)22-12-7-5-11(6-8-12)18(20)21;/h1-8H,(H4,15,16,17);1H | [InChIKey]
PKSBDZOBYIKNGY-UHFFFAOYSA-N | [SMILES]
Cl[H].NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc(cc2)[N+]([O-])=O |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36 | [Safety Statements ]
26 | [WGK Germany ]
3 | [F ]
8-10 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Dam. 1 |
| Hazard Information | Back Directory | [Uses]
4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
- as a substrate for trypsin for active site titration experiments
- for pre-treating of mosquito eggs in the interplasmid transposition assay
- as a component of isotonic buffer to moisten filter paper for mosquito embryo collection
| [General Description]
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay. | [Biochem/physiol Actions]
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening. | [References]
[1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:10.1016/j.bbapap.2017.12.002.
[2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:10.1111/j.1432-1033.1980.tb04829.x.
[3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:10.1016/j.peptides.2008.05.025.
[4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:10.1016/0022-1759(85)90305-9.
[5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:10.1021/jm00154a015. |
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