| Identification | Back Directory | [Name]
(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid | [CAS]
191919-01-4 | [Synonyms]
8-iso-15-keto-PGF2alpha
LOLJEILMPWPILA-RLXHZABYSA-N
8-iso-15-keto Prostaglandin F2α
(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxooct-1-enyl]cyclopentyl]hept-5-enoic acid | [Molecular Formula]
C20H32O5 | [MOL File]
191919-01-4.mol | [Molecular Weight]
352.47 |
| Chemical Properties | Back Directory | [Boiling point ]
535.2±50.0 °C(Predicted) | [density ]
1.149±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
10 mM Na2CO3: >6.5 mg/ml; DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: >10 mg/ml | [pka]
4.76±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits. Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF2α was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF2α. 8-iso -15-keto PGF2α is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.[Cayman Chemical] | [Definition]
ChEBI:8-iso-15-keto-PGF2a is a prostanoid. | [IC 50]
FP | [storage]
Store at -20°C |
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