| Identification | Back Directory | [Name]
(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dienyl]cyclopentyl]hept-5-enoic acid | [CAS]
7045-31-0 | [Synonyms]
8-epi PGF3α
8-iso-PGF3alpha
8-iso Prostaglandin F3α
8-iso Prostaglandin F3α
SAKGBZWJAIABSY-PJCXKLBTSA-N
8-iso Prostaglandin F3α Exclusive
8iso Prostaglandin F3α,8 iso Prostaglandin F3α,8-iso Prostaglandin F-3α
Prosta-5,13,17-trien-1-oic acid, 9,11,15-trihydroxy-, (5Z,8β,9α,11α,13E,15S,17Z)-
(Z)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dienyl]cyclopentyl]hept-5-enoic acid | [Molecular Formula]
C20H32O5 | [MOL File]
7045-31-0.mol | [Molecular Weight]
352.47 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
10 mM Na2CO3: >6.5 mg/ml; DMF: >100 mg/ml; DMSO: >100 mg/ml; Ethanol: >100 mg/ml; PBS pH 7.2: >10 mg/ml |
| Hazard Information | Back Directory | [Description]
8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 μM.1 | [Uses]
8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 μM. | [Definition]
ChEBI: 8-Iso-PGF3alpha is a prostanoid. | [storage]
Store at -20°C | [References]
1. Praticò, D., Smith, E.M., Violi, F., et al. Local amplification of platelet function by 8-epi prostaglandin F2α is not mediated by thromboxane receptor isoforms J. Biol. Chem. 271(25),14916-14924(1996). |
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