| Identification | Back Directory | [Name]
N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid | [CAS]
192203-60-4 | [Synonyms]
CPG2 Inhibitor
Carboxypeptidase G2 Inhibitor
N-[[(4-methoxyphenyl)thio]carbonyl]-
Carboxypeptidase G2 (CPG2) Inhibitor
N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid
L-GlutaMic acid, N-[[(4-Methoxyphenyl)thio]carbonyl]-
N-[[(4-Methoxyphenyl)thio]carbonyl]-L-glutamic acid USP/EP/BP
(2S)-2-[(4-methoxyphenyl)sulfanylcarbonylamino]pentanedioicaci
CPG2 INHIBITOR;L-GLUTAMIC ACID; N-[[(4-METHOXYPHENYL)THIO]CARBONYL]- | [Molecular Formula]
C13H15NO6S | [MDL Number]
MFCD16039212 | [MOL File]
192203-60-4.mol | [Molecular Weight]
313.33 |
| Chemical Properties | Back Directory | [density ]
1.43 | [storage temp. ]
Store at -20°C | [solubility ]
H2O : 1.43 mg/mL (4.56 mM; Need ultrasonic) | [form ]
Powder | [pka]
3.41±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Carboxypeptidase G2 (CPG2) Inhibitor is a novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents. | [References]
[1] Khan, Tariq H.; Eno-Amooquaye, Ebun A.; Searle, Frances et al. Novel Inhibitors of Carboxypeptidase G2 (CPG2): Potential Use in Antibody-Directed Enzyme Prodrug Therapy. Journal of Medicinal Chemistry (1999), 42(6), 951-956. DOI:10.1021/jm990004i
[2] Friedlos F, Lehouritis P, Ogilvie L et al. Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy. Clin Cancer Res. 2008 Jul 1;14(13):4259-66. DOI:10.1158/1078-0432.CCR-07-4800
[3] Schepelmann S, Ogilvie LM, Hedley D et al. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 2007 May 15;67(10):4949-55. DOI:10.1158/0008-5472.CAN-07-0297
[4] Schepelmann S, Hallenbeck P, Ogilvie LM et al. Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2. Cancer Res. 2005 Jun 15;65(12):5003-8. DOI:10.1158/0008-5472.CAN-05-0393 |
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