| Identification | Back Directory | [Name]
PPADS TETRASODIUM SALT | [CAS]
192575-19-2 | [Synonyms]
PPADS
PPADS Tetrasodium
4'-disulfonic acid
PPADS (sodium salt)
PPADS TETRASODIUM SALT
PPADS tetrasodium salt hydrate
Pyridoxalphosphate-6-azophenyl-2'
PPADS tetrasodium salt, anhydrous
pyridoxal-phosphate-6-azophenyl-2',4'- disulfoni
PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID 4NA
PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DI -SULPHONIC ACID TETRAS
PYRIDOXAL-PHOSPHATE-6-AZOPHENYL-2',4'-DISULPHONIC ACID TETRASODIUM
PYRIDOXALPHOSPHATE-6-AZOPHENYL-2',4'-DISULFONIC ACID TETRASODIUM SALT
Pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) tetrasodium salt hydrate
Pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) hydrate tetrasodium salt
4-[(2E)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonatooxymethyl)pyridin-2-ylidene]hydrazinyl]benzene-1,3-disulfonate
4-[[4-FORMYL-5-HYDROXY-6-METHYL-3-[(PHOSPHONOOXY)METHYL]-2-PYRIDINYL]AZO]-1,3-BENZENEDISULFONIC ACID TETRASODIUM
PPADS hydrate tetrasodium salt, 4-[[4-Formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzenedisulfonic acid tetrasodium salt | [Molecular Formula]
C14H10N3Na4O12PS2 | [MDL Number]
MFCD00153865 | [MOL File]
192575-19-2.mol | [Molecular Weight]
599.3 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
H2O: >10 mg/mL
| [form ]
solid
| [color ]
red to orange
| [Water Solubility ]
Soluble to 100 mM in water | [Stability:]
Unstable in Aqueous Solution |
| Hazard Information | Back Directory | [Uses]
P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors. PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats. | [Uses]
PPADS Tetrasodium is an non-selective purinergic antagonists of P2 ATP receptors. PPADS Tetrasodium is also a potential neuroprotective agents for the treatment of autoimmune and demyelinating disease
. | [Definition]
ChEBI: Tetrasodium 5'-phosphonatopyridoxal-6-azobenzene-2,4-disulfonate is an organic sodium salt that is the tetrasodium salt of 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid It has a role as a purinergic receptor P2X antagonist. It is an organic sodium salt and an organosulfonate salt. It contains a 5'-phosphonatopyridoxal-6-azobenzene-2,4-disulfonate. | [Biological Activity]
Non-selective P2 purinoceptor antagonist which blocks responses at both pre- and post-junctional sites. | [storage]
Desiccate at -20°C |
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| Company Name: |
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| Tel: |
821-50328103-801 18930552037 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm |
| Company Name: |
Energy Chemical
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021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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