| Identification | Back Directory | [Name]
N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 | [CAS]
193611-67-5 | [Synonyms]
SB 216641A
N-[3-[3-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide hydrochloride PFI-3 | [Molecular Formula]
C28H31ClN4O4 | [MOL File]
193611-67-5.mol | [Molecular Weight]
523.03 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at RT | [solubility ]
DMSO: soluble; Water: soluble | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 50 mM in water |
| Hazard Information | Back Directory | [Uses]
SB 216641 Hydrochloride is a selective SR-1B and 5-HT1B antagonist. | [in vivo]
SB-216641A (0.6-20 mg/kg; i.p.; single dose) hinders the SKF-99101H induced hypothermia with dose-dependent manner in guinea pigs[1].
SB-216641A (559 nmol/kg; i.v.; single dose) improves the gastric relaxation observed after injection of 800 nmol/kg Sumatriptan (HY-B0121B) in dogs when combined with 5-HT1B/D receptor antagonist GR-127935[2]. | Animal Model: | Guinea pigs[1]. | | Dosage: | 0.6, 2.0, 6.0 and 20.0 mg/kg. | | Administration: | Intraperitoneal injection; single dose. | | Result: | Significantly blocked the effects of SKF-99101H. |
| Animal Model: | Dogs[2]. | | Dosage: | 559 nmol/kg. | | Administration: | Intravenous injection; single dose. | | Result: | Improved the gastric relaxation. |
| [IC 50]
5-HT1B Receptor; 5-HT1D Receptor | [storage]
Store at RT |
|
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