| Identification | Back Directory | [Name]
JNJ-38877605-d1 | [CAS]
1936472-36-4 | [Synonyms]
JNJ-38877605-d1
Quinoline-2-d, 6-[difluoro[6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]- | [Molecular Formula]
C19H12DF2N7 | [MOL File]
1936472-36-4.mol | [Molecular Weight]
378.36 |
| Hazard Information | Back Directory | [Uses]
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3[1]. | [References]
[1] Sikkema BJ, et al. Quantification and clinical validation of the selective MET kinase inhibitor DO-2 and its metabolites DO-5 and M3 in human plasma. J Pharm Biomed Anal. 2024 Jan 4;240:115962. DOI:10.1016/j.jpba.2024.115962 |
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