| Identification | Back Directory | [Name]
PubChem ID: 9887472 | [CAS]
194414-69-2 | [Synonyms]
PubChem ID: 9887472
Camptothecin-20(S)-O-propionate | [Molecular Formula]
C23H20N2O5 | [MDL Number]
MFCD32708502 | [MOL File]
194414-69-2.mol | [Molecular Weight]
404.42 |
| Chemical Properties | Back Directory | [Melting point ]
250-252 °C (decomp) | [Boiling point ]
740.3±60.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 9.09 mg/mL (22.48 mM) | [form ]
Solid | [pka]
4?+-.0.40(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3]. | [in vivo]
Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice[3]. | Animal Model: | A tumor xenograft growing in a nude mouse (size, ～1 cm3)[3]. | | Dosage: | 100-1000 mg/kg/day. | | Administration: | Oral gavage, for 2, 4 and 6 days, respectively. | | Result: | Exhibited anti-tumor effect. |
| [storage]
Store at -20°C | [References]
[1] Xing Liu, et al. Correlation between the sensitivity of tumors to treatment with CZ48 and local concentrations of the active metabolite CPT within the tumors. Biomed Rep. 2013 Mar;1(2):202-206. DOI:10.3892/br.2013.55
[2] Zhisong Cao, et al. Crystalline camptothecin-20(S)-O-propionate hydrate: a novel anticancer agent with strong activity against 19 human tumor xenografts. Cancer Res. 2009 Jun 1;69(11):4742-9. DOI:10.1158/0008-5472.CAN-08-4452 |
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