| Identification | Back Directory | [Name]
TETRAGASTRIN | [CAS]
1947-37-1 | [Synonyms]
TETRAGASTRIN
CCK-4 Acetate
Trp-Met-Asp-Phe amide
Cholecystokinin(36-39)
Tetragastrin hydrochloride
H-Trp-Met-Asp-Phe-NH2 acetate
Cholecystokinin, CCK Tetrapeptide
CCK-4 Acetate, Gastrin Tetrapeptide
4-7-Cholecystokinin-7 (swine) (9CI)
Cholecystokinin fragment 30-33 amide
Cholecystokinin C-terminal tetrapeptide
Gastrin Tetrapeptide H-Trp-Met-Asp-Phe-NH2
Cholecystokinin Fragment 30-33 Amide >=95% (HPLC)
L-Phenylalaninamide, L-tryptophyl-L-methionyl-L-α-aspartyl-
L-Phenylalaninamide, L-tryptophyl-L-methionyl-L-a-aspartyl-
Alaninamide, L-tryptophyl-L-methionyl-L-aspartylphenyl- (7CI)
Alaninamide, L-tryptophyl-L-methionyl-L-aspartylphenyl-, L- (8CI)
Cholecystokinin Tetrapeptide, Cholecystokinin Octapeptide (5-8), CCK-4, Gastrin (14-17) (huMan)
(3S)-3-[[(1S)-1-carbamoyl-2-phenyl-ethyl]carbamoyl]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-phenylmethoxycarbonylamino-propanoyl]amino]-4-methylsulfanyl-butanoyl]amino]propanoic acid | [Molecular Formula]
C37H42N6O8S | [MDL Number]
MFCD01741579 | [MOL File]
1947-37-1.mol | [Molecular Weight]
730.83 |
| Chemical Properties | Back Directory | [Melting point ]
185-195 °C | [Boiling point ]
1070.0±65.0 °C(Predicted) | [density ]
1.348±0.06 g/cm3(Predicted) | [storage temp. ]
?20°C | [solubility ]
DMF: 20mg/mL, clear, colorless to yellow | [form ]
Solid | [pka]
4.19±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
RGYLYUZOGHTBRF-BIHRQFPBSA-N | [SMILES]
CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O |
| Safety Data | Back Directory | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Toxicity]
dog,LD,intravenous,> 100mg/kg (100mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: EXCITEMENT,Oyo Yakuri. Pharmacometrics. Vol. 3, Pg. 121, 1969. |
| Hazard Information | Back Directory | [Hazard]
Moderately toxic by ingestion | [Uses]
Cholecystokinin Fragment 30-33 Amide can be used for inactivating the CCK8 antiserum. The product can also be used as an antigen utilized in absorption control for testing the specificity of antisera. | [Definition]
ChEBI: Tetragastrin is a tetrapeptide composed of L-tryptophan, L-methione, L-aspartic acid and L-phenylalaninamide residues joined in sequence. It has a role as an anxiogenic and a human metabolite. It is a tetrapeptide and a peptidyl amide. | [Biochem/physiol Actions]
Cholecystokinin Fragment 30-33 Amide also referred to as CCK-4 or Trp-Met-Asp-Phe amide is a peptide fragment derived from peptide hormone cholecystokinin. CCK-4 is a panicogenic agent that induces panic attacks in humans. This property of the compound can be used in scientific research for testing the new anxiolytic drugs. | [in vivo]
In inbred Wistar rats treated with N-methyl-N'-nitro-N-nitrosoguanidine, Tetragastrin (s.c.; 1 mg/kg; every other day) treatment significantly reduces the incidence and the number of adenocarcinomas, and has a significantly lower labelling index of the antral mucosa[1].
Tetragastrin has potential for enhancing gastric mucosal protection associated with mucus secretion and/or mucus synthesis on the surface mucosa of rat gastric mucosa. A significant increase in the mucin content was noted in the mucus gel and surface mucosal layer. An increase in mucin in the mucus gel and surface mucosa would thus appear due to the administration of Tetragastrin[3]. | Animal Model: | Seven-week-old male Wistar rats, each weighing approximately 160 g[3] | | Dosage: | 12, 120, or 400 μg/kg | | Administration: | Administered subcutaneously (s.c.); followed by 50% ethanol-induced gastric injury | | Result: | Caused a significant increase in mucin content in the corpus mucosa and prevented 50% ethanol-induced gastric mucosal damage in a dose-dependent manner. |
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BOC Sciences
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https://www.bocsci.com |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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