| Identification | Back Directory | [Name]
L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- | [CAS]
1948273-02-6 | [Synonyms]
CPD101077
(S,R,S)-AHPC-Me
E3 ligase Ligand 1A
E3 ligase Ligand 1
(free base)
L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide | [Molecular Formula]
C23H32N4O3S | [MDL Number]
MFCD31630815 | [MOL File]
1948273-02-6.mol | [Molecular Weight]
444.59 |
| Chemical Properties | Back Directory | [Boiling point ]
687.9±55.0 °C(Predicted) | [density ]
1.233±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
Solid | [pka]
14.00±0.40(Predicted) | [color ]
White to yellow | [InChIKey]
JOSFQWNOUSNZBP-UUZHKXTQSA-N | [SMILES]
C(N[C@H](C1=CC=C(C2SC=NC=2C)C=C1)C)(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)(C)C)N |
| Hazard Information | Back Directory | [Description]
E3 Ligase ligand 1a is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 Ligase ligand 1a can be used to synthesize ARV-771, a BET PROTAC degrader. | [Uses]
(4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide, is a ligand of E3 ligase, | [IC 50]
VHL |
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