| Identification | Back Directory | [Name]
DISIALOGANGLIOSIDE GD1B 2NA | [CAS]
19553-76-5 | [Synonyms]
Gd1b
GD1B 2NA
Aids002546
Aids-002546
Ganglioside C1
Ganglioside G2
Ganglioside giii
GD1B-GANGLIOSIDE
GD1B (NH4+ SALT)
ganglioside, GD1b
II3(NEUAC)2-GGOSE4CER
DISIALOGANGLIOSIDE-GD1B
GD1b-Ganglioside sodium
ganglioside gd1b, disialo
DISIALOGANGLIOSIDE GD1B 2NA
II3(NEU5NAC)2GGOSE4 CERAMIDE
DISIALOGANGLIOSIDE GD1B, HUMAN
Ganglioside GD1b (sodium salt)
GANGLIOSIDE GD1B DISODIUM SALT
DISIALOGANGLIOSIDE GD1B, BOVINE
Ganglioside G2 (hexasaccharide)
Ganglioside gd1B polysaccharide
GANGLIOSIDE GD1B, DISIALO, HUMAN
DISIALOGANGLIOSIDE GD1B (NH4+ SALT)
II3(NEU5NAC)2GGOSE4 CERAMIDE, HUMAN
Ganglioside GD1b Mixture (sodium salt)
GANGLIOSIDE GD1B, DISIALO, HUMAN BRAIN
GANGLIOSIDEGD1BDISODIUMSALT,BOVINEBRAIN
MONOSIALOGANGLIOSIDE GD1B DISODIUM SALT
II3(NEU5AC)2GGOSE4 CERAMIDE, 2NH4, BOVINE
disialoganglioside G(D1B) from bovine brain
GD1b ganglioside disodium salt (bovine brain)
GANGLIOSIDE GD1B, DISIALO, DIAMMONIUM SALT, BOVINE
Ganglioside GD1b, Disialo, Diammonium Salt, Bovine Brain
Neu5Acα2, 8Neu5Acα2, 3(Galβ1, 3GalNAcβ1, 4)Galβ1, 4Glc Ceramide
GAL-BETA1,3GALNAC-BETA1,4(NEU5AC-ALPHA2,8)(NEU5AC-ALPHA2,3)GAL-BETA1,1' CERAMIDE
GALBETA1,3GALNACBETA1,4(NEU5ACALPHA2,8)(NEU5ACALPHA2,3)GALBETA1-4GLCBETA1,1' CERAMIDE
Neu5Aca2,8Neu5Aca2,3(Galb1,3GalNAcb1,4)Galb1,4Glc Ceramide Synonym:GD1b
GAL-BETA1,3GALNAC-BETA1,4(NEU5AC-ALPHA2,8)(NEU5AC-ALPHA2,3)GAL-BETA1-4GLC-BETA1,1' CERAMIDE, HUMAN
beta-Gal-(1->3)-beta-GalNAc-(1->4)-[alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)]-beta-Gal-(1->4)-beta-Glc-(1<->1')-Cer | [Molecular Formula]
C84H148N4O40 | [MDL Number]
MFCD00466941 | [MOL File]
19553-76-5.mol | [Molecular Weight]
1854.08 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [solubility ]
Chloroform:Methanol:DI Water (2:1:0.1): soluble | [form ]
lyophilized powder | [InChIKey]
AIUBMTQAHKTQMI-MPGPKOMUSA-N |
| Hazard Information | Back Directory | [Description]
Ganglioside GD1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events. The concentration of ganglioside GD1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects. Ganglioside GD1b levels are positively correlated with pilocytic astrocytoma tumor grade, and GD1b has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas. Ganglioside GD1b mixture contains ganglioside GD1b molecular species with C18:1 and C20:1 fatty acyl chains. | [Uses]
Ganglioside GD1b Disodium Salt (Bovine Brain) is a ganglioside, major constituents of neuronal cell membranes and endoplasmic reticulum that have been shown to modulate cell signal transduction. | [General Description]
Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980. | [Biochem/physiol Actions]
May act as a bacterial toxin receptor (tetanus, botulinus); high levels found in gliomas and astrocytomas. | [References]
[1] L RIBONI. Natural occurrence of ganglioside lactones. Isolation and characterization of GD1b inner ester from adult human brain.[J]. The Journal of Biological Chemistry, 1986, 261 18: 8514-8519.
[2] T. COMAS. Immunohistochemical staining for ganglioside GD1b as a diagnostic and prognostic marker for primary human brain tumors.[J]. Neuro-oncology, 1999, 1 4 1: 261-267. DOI: 10.1093/neuonc/1.4.261 |
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