| Identification | Back Directory | [Name]
4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl | [CAS]
1957235-66-3 | [Synonyms]
Pomalidomide-C2-NH2
4-[(2-Aminoethyl)amino]-2-(2
Cereblon Ligand-Linker Conjugates 15
Pomalidomide-C2-NH2(E3 ligase Ligand 17)
4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)- | [Molecular Formula]
C15H16N4O4 | [MDL Number]
MFCD31729301 | [MOL File]
1957235-66-3.mol | [Molecular Weight]
316.31 |
| Chemical Properties | Back Directory | [Boiling point ]
633.6±55.0 °C(Predicted) | [density ]
1.496±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.74±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Pomalidomide-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology. | [IC 50]
Cereblon | [References]
[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168 |
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