| Identification | Back Directory | [Name]
Pomalidomide-C6-NH2?hydrochloride | [CAS]
2375194-37-7 | [Synonyms]
Thalidomide-NH-C6-NH2 HCl
Pomalidomide-C6-NH2?hydrochloride
4-((6-aminohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | [Molecular Formula]
C19H25ClN4O4 | [MOL File]
2375194-37-7.mol | [Molecular Weight]
408.88 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-NH-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [reaction suitability]
reactivity: carboxyl reactive
reagent type: ligand-linker conjugate | [IC 50]
Cereblon | [References]
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
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ChemShuttle, Inc.
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0150-83588313-811 18800520310 |
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www.jiehuapharma.com/ |
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