| Identification | Back Directory | [Name]
Panaxadiol | [CAS]
19666-76-3 | [Synonyms]
Panaxadio
PANAXADIOL
Panaxaidol
Panaxadiol ,98%
(20R)-Panaxadiol
Panaxquinquefolium L.
PANAXADIOL 98.0% BY HPLC
DAMMARANE-3BETA,12BETA-DIOL
(20R)-20,25-Epoxy-5α-dammarane-3β,12β-diol
PALMITIC ACID METHYLESTER 99%(RG) (SEE METHYL PALMITATE) | [Molecular Formula]
C30H52O3 | [MDL Number]
MFCD00210540 | [MOL File]
19666-76-3.mol | [Molecular Weight]
460.73 |
| Chemical Properties | Back Directory | [Melting point ]
250℃ | [Boiling point ]
531.3±45.0 °C(Predicted) | [density ]
1.025±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [pka]
14.82±0.70(Predicted) | [color ]
White to Off-White | [InChIKey]
PVLHOJXLNBFHDX-VOXQHZRYNA-N | [SMILES]
[C@@]12(C)CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]1([H])C[C@@H](O)[C@]1([H])[C@H](CC[C@@]21C)[C@@]1(C)CCCC(C)(C)O1 |&1:0,4,9,13,15,18,20,22,25,27,r| | [CAS DataBase Reference]
19666-76-3 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Uses]
Panaxadiol is the purified sapogenin of ginseng saponins, which exhibits anti-tumor activity. Research has shown Panaxadiol exhibited enhancing activity towards human colorectal cancer cells. | [Definition]
ChEBI: Panaxadiol is a triterpenoid saponin. | [in vivo]
Panaxadiol (oral gavage; 10 or 30 mg/kg; once every 3 days; 30 d) inhibits the growth of HCT116 cells in a xenograft model[1].
| Animal Model: | BALB/c athymic nude mice injected with HCT116 cells[1] | | Dosage: | 10 or 30 mg/kg | | Administration: | Oral gavage; 10 or 30 mg/kg; once every 3 days; 30 days | | Result: | Inhibited the protein levels of HIF-1α, p-STAT-3 (Tyr705), PD-L1 and VEGF in tumour tissues in a dose-dependent manner. |
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