| Identification | More | [Name]
Estradiol | [CAS]
57-91-0 | [Synonyms]
1,3,5(10)-ESTRADRIEN-3,17A-DIOL
1,3,5(10)-ESTRATRIEN-2,17BETA-DIOL
1,3,5(10)-ESTRATRIEN-3,17-ALPHA-DIOL
1,3,5(10)-ESTRATRIEN-3,17-BETA-DIOL
1,3,5(10)-ESTRATRIEN-3,17-DIOL
1,3,5[10]-ESTRATRIENE-3,17ALPHA-DIOL
1,3,5[10]-ESTRATRIENE-3,17BETA-DIOL
1,3,5-ESTRATRIENE-3,17-BETA-DIOL
17A-ESTRADIOL
17ALPHA-ESTRADIOL
17B-ESTRADIOL
17BETA-ESTRADIOL
17BETA-OESTRADIOL
3,17ALPHA-DIHYDROXY-1,3,5[10]-ESTRATRIENE
3,17BETA-DIHYDROXY-1,3,5[10]-ESTRATRIENE
3,17-DIHYDROXYESTRATRIENE
(8R,9S,13S,14S,17S)-13-METHYL-7,8,9,11,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,17-DIOL
ALPHA-ESTRADIOL
B-ESTRADIOL
BETA-ESTRADIOL | [EINECS(EC#)]
200-023-8 | [Molecular Formula]
C18H24O2 | [MDL Number]
MFCD00064144 | [Molecular Weight]
272.38 | [MOL File]
57-91-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
176-180 °C(lit.)
| [alpha ]
D20 +53 to +56° (c = 0.9 in dioxane) | [Boiling point ]
355.44°C (rough estimate) | [density ]
1.0708 (rough estimate) | [refractive index ]
1.4800 (estimate) | [storage temp. ]
0-6°C | [solubility ]
ethanol: 50 mg/mL, clear, colorless
| [form ]
powder
| [pka]
10.27±0.60(Predicted) | [color ]
white with slight yellow cast
| [biological source]
synthetic (organic) | [Water Solubility ]
3.9mg/L(25 ºC) | [Merck ]
13,3738 | [InChI]
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1 | [InChIKey]
VOXZDWNPVJITMN-SFFUCWETSA-N | [SMILES]
[H][C@]12CC[C@]3(C)[C@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(O)ccc24 | [CAS DataBase Reference]
57-91-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0) | [EPA Substance Registry System]
Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS08,GHS09 | [Signal word ]
Danger | [Hazard statements ]
H341-H351-H360F-H362-H410 | [Precautionary statements ]
P201-P202-P260-P263-P273-P308+P313 | [Hazard Codes ]
T,Xn | [Risk Statements ]
R45:May cause cancer.
R48:Danger of serious damage to health by prolonged exposure.
R40:Limited evidence of a carcinogenic effect. | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
KG3750000
| [F ]
8-10 | [HS Code ]
29372390 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Aquatic Chronic 1
Carc. 2
Lact.
Muta. 2
Repr. 1A |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke. | [Definition]
ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer). | [Biological Activity]
Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively). | [Biochem/physiol Actions]
Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke. | [target]
Beta Amyloid | Bcl-2/Bax | Caspase | PARP | Estrogen receptor | GABA Receptor | Progestogen receptor | [storage]
Room temperature | [Purification Methods]
17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
T&W GROUP
|
| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
|