| Identification | More | [Name]
3,3'-Diindolylmethane | [CAS]
1968-05-4 | [Synonyms]
3,3'-DIINDOLYLMETHANE
3,3'-METHYLENEBIS-1H-INDOLE
3,3'-METHYLENEBISINDOLE
3,3'-METHYLENEDIINDOLE
3-DIINDOLYL METHANE
ARUNDINE
BIS(3-INDOLYL)METHANE
DI-3-INDOLYLMETHANE
DI INDOLYL METHANE
DI-INDOYLMETHANE, 3,3'-
DIM
Indolyl-CH2-Indolyl
2-carboxy-5-nitrobenzne sulfonic acid
DIINDOLYLMETHANE(DIM)
3,3-DI-INDOLY-METHANE
Indole dimer
Diindole methane
3,3’-Diindolylmethane 3,3'-Methylenebisindole
3,3'-methylene-bisindole | [EINECS(EC#)]
100-201-5 | [Molecular Formula]
C17H14N2 | [MDL Number]
MFCD00195766 | [Molecular Weight]
246.31 | [MOL File]
1968-05-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
167 °C | [Boiling point ]
230 °C(Press: 0.01 Torr) | [density ]
1.271±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Sparingly), Methanol (Slightly) | [form ]
Off-white powder. | [pka]
16.91±0.30(Predicted) | [color ]
White to Pale Beige | [Major Application]
food and beverages | [InChI]
InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2 | [InChIKey]
VFTRKSBEFQDZKX-UHFFFAOYSA-N | [SMILES]
C(C1C2=C(NC=1)C=CC=C2)C1C2=C(NC=1)C=CC=C2 | [LogP]
4.401 (est) | [CAS DataBase Reference]
1968-05-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335-H413 | [Precautionary statements ]
P273-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3 | [RTECS ]
NM0332000 | [HazardClass ]
IRRITANT | [HS Code ]
29349990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Chronic 4
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Solid | [Uses]
An antineoplastic agent that activates Chk 2 and cytochrome p450 | [Uses]
apoptosis inducer | [Definition]
ChEBI: 3,3'-diindolylmethane is a member of indoles. It has a role as an antineoplastic agent and a P450 inhibitor. | [General Description]
3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects. | [Biological Activity]
3,3'-diindolylmethane is an anticancer agent [1].3,3'-diindolylmethane (dim) is a dimer of indole-3-carbinol generated in low ph environment. it inhibited cell growth with ic50 values of 17, 24 and 30 μm in mcf-7, t47d and saos2 cell lines, respectively. dim induced apoptosis in these cells without affecting the p53 pathway. in human nasopharyngeal carcinoma (npc) cell line (5-8f npc), treatment of dim decreased the ability of cell migration and invasion dose-dependently. in rats, transplanted with npc cells, dim administration resulted in suppressing lymph node metastasis. besides that, dim was found to induce erα target gene expression and the concomitant cell proliferation at low concentration (10μm) in the absence of e2 [1, 2 and 3]. | [Biochem/physiol Actions]
Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system. | [Synthesis]
Indole (1.17 g,10 mmol), CTAB (50% mol) and oxalic acid (50% mol) were placed in a 25 ml single-necked round-bottomed flask, 5 ml of deionized water was added and stirred thoroughly for 5 min, then an aqueous solution of formaldehyde (0.38 g of solutio | [References]
1. ge x, yannai s, rennert g, et al. 3, 3′-diindolylmethane induces apoptosis in human cancer cells. biochemical and biophysical research communications, 1996, 228(1): 153-158. 2. wu t, chen c, li f, et al. 3, 3' diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. experimental and therapeutic medicine, 2014, 7(6): 1635-1638. 3. marques m, laflamme l, benassou i, et al. low levels of 3, 3 [prime]-diindolylmethane activate estrogen receptor alpha and induce proliferation of breast cancer cells in the absence of estradiol. bmc cancer, 2014, 14(1): 524. |
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J & K SCIENTIFIC LTD.
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https://www.jkchemical.com |
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jiliang chemicals
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21-62165282 |
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http://www.jiliangchem.com |
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277 |
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www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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