| Identification | Back Directory | [Name]
DL-METHIONINE DL-SULFOXIMINE | [CAS]
1982-67-8 | [Synonyms]
CNESTINE
AURORA KA-705
dl-sulfoximin
METHIONINESULPHOXIME
methioninesulfoximine
DL-METHIONINE SULFOXIMINE
DL-LOBAMINE-DL-SULFOXIMINE
dl-methionine-dl-sulfoximin
L-METHIONINE-RS-SULPHOXIMINE
DL-METHIONINE DL-SULFOXIMINE
DL-METHIONINE-DL-SULPHOXIMINE
DL-BANTHIONINE-DL-SULFOXIMINE
2-Amino-4-(S-methylsulfonimidoyl)butyric acid
2-amino-4-(s-methylsulfonimidoyl)-butanoicaci
2-amino-4-(s-methylsulfonimidoyl)butanoicacid
2-amino-4-(S-methylsulphonimidoyl)butyric acid
DL-[3-AMINO-3-CARBOXYPROPYL]METHYL SULFOXIMINE
Butanoic acid, 2-amino-4-(S-methylsulfonimidoyl)-
SULPHOXIMINE,S-(3-AMINO-3-CARBOXYPROPYL)-S-METHYL-,DL- | [EINECS(EC#)]
217-845-8 | [Molecular Formula]
C5H12N2O3S | [MDL Number]
MFCD00063094 | [MOL File]
1982-67-8.mol | [Molecular Weight]
180.23 |
| Chemical Properties | Back Directory | [Melting point ]
214-218 °C (decomp) | [Boiling point ]
352.2±52.0 °C(Predicted) | [density ]
1.215 (estimate) | [refractive index ]
1.6430 (estimate) | [storage temp. ]
2-8°C | [form ]
Solid | [color ]
White to off-white |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3 | [RTECS ]
WS3560000 | [HS Code ]
29252900 | [Toxicity]
mouse,LD50,intraperitoneal,218mg/kg (218mg/kg),Proceedings of the Society for Experimental Biology and Medicine. Vol. 94, Pg. 12, 1957. |
| Hazard Information | Back Directory | [Uses]
Methionine sulfoximine (2-Amino-4-(S-methylsulfonimidoyl)butanoic acid) is an irreversible inhibitor of glutamine synthetase with convulsive effects. Methionine sulfoximine is able to affect the metabolism of glutamate and glutamine, which may provide important insights in neurobiological research. Methionine sulfoximine has also been used to study mechanisms related to epilepsy and its inhibitory potential[1]. | [Definition]
ChEBI: A non-proteinogenic alpha-amino acid that is the sulfoximine derivative of methionine . | [References]
[1] Catalytic cooperativity and subunit interactions in Escherichia coli glutamine synthetase: binding and kinetics with methionine sulfoximine and related inhibitors |
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