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63-68-3 Structure

63-68-3 Structure




[Molecular Formula]

[MDL Number]

[Molecular Weight]

[MOL File]

Chemical PropertiesBack Directory

White crystalline powder
[mp ]

284 °C (dec.)(lit.)
[alpha ]

23.25 º (c=2, 6N HCl)
[density ]

[storage temp. ]

Store at RT.
[solubility ]

1 M HCl: 0.5 M at 20 °C, clear, colorless

Stable. Incompatible with strong oxidizing agents.
[Water Solubility ]

[Merck ]

[BRN ]


methionine is slows down and normalizes oil gland sebum production. Methionine is also used as a texturizer in cosmetic creams. It is an essential amino acid found in a number of proteins and obtained by means of fermentation.
[CAS DataBase Reference]

63-68-3(CAS DataBase Reference)
[NIST Chemistry Reference]

[EPA Substance Registry System]

63-68-3(EPA Substance)
Safety DataBack Directory
[Risk Statements ]

R33:Danger of cumulative effects.
[Safety Statements ]

S24/25:Avoid contact with skin and eyes .
[WGK Germany ]


[F ]

[HS Code ]

[Safety Profile]

Mildly toxic by ingestion and intraperitoneal routes. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. An essential sulfur-containing amino acid. When heated to decomposition it emits very toxic fumes of NOx and SOx.
[Hazardous Substances Data]

63-68-3(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
【Raw materials】

Ammonium bicarbonate-->Acrolein-->Potassium sulfate-->Cupric acetate monohydrate-->METHYL MERCAPTAN-->Potassium bisulfate-->Storage tank-->Sodium hydroxide-->Ammonium chloride-->Sodium cyanide
【Preparation Products】

Hazard InformationBack Directory
[General Description]

Minute hexagonal plates from dilute alcohol.
[Reactivity Profile]

An organosulfide and amine derivative, carboxylic acid. Look at Reactive Groups 20 (organosulfides), 7 (amines), and 3 (carboxylic acids) may give indications about reactive tendencies. L-METHIONINE(63-68-3) is an amino acid essential in human nutrition.
[Air & Water Reactions]

Reacts with water, steam, and/or acids to produce toxic and flammable vapors of hydrogen sulfide . Water soluble . pH of 1% aqueous solution is 5.6-6.0.
[Health Hazard]

ACUTE/CHRONIC HAZARDS: This material is dangerous when heated to decomposition; it emits dangerous and highly toxic fumes.
[Fire Hazard]

Flash point data for this material is not available, but L-METHIONINE is probably combustible.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Questions And AnswerBack Directory

L-methionine is a sulfur-containing essential L-amino acid that is important in many body functions. Methionine is a dietary indispensable amino acid required for normal growth and development of humans, other mammals, and avian species. In addition to being a substrate for protein synthesis, it is an intermediate in transmethylation reactions, serving as the major methyl group donor.It must be obtained from diet and food sources since it is unable to be biosynthesized in the body. The minimum daily requirement of L-methionine for an adult male is 13 milligrams per kilogram of body weight. This quantity is normally easy to obtain from a complete diet.
Methionine is accepted as the metabolic precursor for cysteine. Only the sulfur atom from methionine is transferred to cysteine; the carbon skeleton of cysteine is donated by serine. (PMID: 16702340).It helps the body produce SAMe (S-Adenosyl-L-methionine), which has been used to treat psychiatric illnesses, infertility, liver problems, premenstrual disorders, and musculoskeletal conditions. Studies on SAMe have shown that it is as effective as tricyclic antidepressants in alleviating depression.
Ongoing studies that show promise are also being conducted to determine how effective L-Methionine may be for treating HIV/AIDS, liver damage, Parkinson's disease, and urinary tract infections.
[chemical properties]

L-methionine’s scientific name is methylthiobutanenitrile acid and is one of the essential amino acids. It is white flaky crystal or crystalline powder with specific odor. Its relative molecular weight is 149.21. DL-methionine(racemic)m.p. 281℃(decomposition). Its relative density is 1.340. It is soluble in water, dilute acid and dilute alkali solution and slightly soluble in 95% ethanol, which is insoluble in ether. L-methionine (L-body) melting point 280~281℃(decomposition). It is soluble in hot water and alcohol, which is insoluble in ethanol, ethyl ether, petroleum ether, benzene and acetone. D-methionine (D-body) Melting point 273 ℃ (decomposition). It is soluble water, acid and alkal and very slightly soluble in alcohol, insoluble in ether. Usually right-handed amino acids in body are invalid in biochemistry. However, this is the exception of methionine. D-methionine and L-methionine both are effective accelerator. This is due to the D-methionine in vivo can be converted into L-methionine. Therefore, the synthesis of DL-methionine does not require an analysis of points and can be used for the direct application. L-Methionineis one of the essential amino acids in the animal body, which is one of the components of the protein. It can maintain the growth and development of the body and balance nitrogen. It cannot be synthesized in animals in vivo and must be supplied in the form of amino acids or proteins from in vitro. L-Methionineis an important feed additive (nutrition enhancer). On the medical side, L-Methionineis one of the major components of amino acid infusion and compound amino acid preparation. It is also used for the prevention and treatment of liver disease and arsenic, benzene poisoning. It is also used as protein nutritional supplements for patients with protein deficiency or inadequate absorption. It can be obtained through the following steps: by the addition of methyl mercaptan and acrolein and then reacted with sodium cyanide and ammonium chloride .This step generates α-aminonitrile and then via hydrolysis to get the target production. It can also be obtained by hydrolysis of casein and then refined.
[Feed additives]

L-Methionine is mainly used as feed nutritional supplements and one of the essential amino acids in the growth of animals, which is the "skeleton" amino acid in protein biosynthesis and main donor of methyl in animal body. L-Methionineplays a certain role in the process of synthesis of choline by adrenal hormone and fatty liver phospholipids during the process of metabolism of the animal in vivo. Lacking of L-Methioninein livestock and poultry will lead to poor development, weight loss, liver and kidney function decline, muscle atrophy, fur deterioration, etc.
L-Methionine is a sulfur amino acid and the second limiting essential amino acids for pigs. The utilization ratio of feed protein can be improved effectively if lysine and L-Methioninewere added in the feed appropriately. So the lysine and L-Methionineare called enhancer for protein feed. Naturally occurring L-Methioninehas two types: D type and L type two and their biological utilization rate is identical. Synthetic L-Methionineis a type DL compound of type D and type L. The biological potency of compound is the same as that of the single D or L-methionine. The appearance of DL methionine additive is white to pale yellow crystal or crystalline powder and insoluble in water and has slightly sweetness haste. The content of L-Methioninein feed of pig is generally from 0.05% to 0.1%.
L-Methionineas a nutritional supplement, the effect of the type L is the same as that of the type of DL (due to the type L transformed from the type DL). Feed additives; as the product and cysteine both belong to sulfur-containing amino acids, so a large amount of them exist in animal proteins. However, it belongs to limiting amino acids in plant proteins such as oats, rye, rice, corn, wheat, peanuts, soybeans, potatoes, spinach and other vegetable foods and the content is less than animal proteins.So it can be added to the above food to improve the balance of amino acids. In the past, sulphur-containing amino acids were thought to be only suitable for non-ruminants. But now the experiment has been proved that it is applicable to the non-ruminants. It is more suitable for chicken and pig feed. On the medical side, it can be used for infusion together with other amino acids. Also used as a culture medium during fermentation.

L-Methionineis a sulfur-containing amino acid. Choline is synthesized in vivo by the L-Methioninesupplying the required methyl. And choline is a component of lecithin. Lecithin is an essential material for the removal of fat from the liver and the deposition of fat in the liver. So L-Methioninealso has an effect in choline lipotropic. In addition, L-Methioninein vivo supplies sulfur to synthesize non-exogenous amino acid Cys. The latter has the function of detoxification. Therefore, this medicine is used for the liver lipotropic in clinical , which is Suitable for fatty liver and chronic hepatitis and liver cirrhosis with fat infiltration. Clinical L-Methioninecan also be used as an adjuvant therapy drug for alcohol and poisoning.
[Amino acids]

Amino acids are the constituent units of the protein and are the material basis of life. From as large as human beings to as small as microorganism, they are both made up of proteins. Proteins are composed of peptides and peptide chains of peptides are composed of amino acids. Different proteins are made of peptide chains which are composed of amino acids in a different order and length. Genetically related genes are actually different sequences of amino acid chains. At present, there are total 28 kinds of amino acids related to the human body. These 28 amino acids are arranged in a different order and different length of the chain to compose the various parts proteins of the body. Of these 28 kinds of amino acids, nine species (about 32%) are required by the direct supply of dietary protein amino acids. They cannot be synthesized by other amino acids in the proteins that are taken in by the human body. They are leucine, isoleucine, valine, lysine, methionine, tryptophan, threonine, phenylalanine and histidine.
L-Methionineis an essential amino acid. It can help break down fat. So it can prevent fatty liver, heart disease, cerebrovascular disease and renal disease. The synthesis of amino acids, such as cysteine and taurine, requires the assistance of methionine.
This amino acid can help to remove harmful substances, such as lead and other heavy metals. It can prevent muscle weakness and brittle hair. It is also good for the prevention and treatment of osteoporosis or chemical allergies. It is good for the treatment of rheumatic fever and pregnancy toxemia.
L-Methionineis still a potent antioxidant. The sulfur L-Methioninewhich contains can eliminate free radicals. The synthesis of nucleic acids, collagen and protein in the body all require methionine. It is also good to take L-Methioninefor women taking contraceptives. Because the level of histamine in the blood of patients with schizophrenia is much higher than that of normal people, it can reduce the level of histamine in the body. Therefore, it is effective for the treatment of schizophrenia. If the body's toxic substances increase, the need for L-Methioninealso increases. As the body can change the L-Methionineinto cysteine, and cysteine is the precursor of glutathione; and glutathione is the main toxic liver neutralizers. So it will be able to protect the liver from harm toxic substances.
Methionine-rich foods: beans, other legumes, eggs, fish, garlic, meat, onions and yogurt.

LD50 36g/kg (rat, oral)
Safe for food (FDA§172.320,2000)

  • Amino acid drugs, nutritional supplements. Used for fatty liver and cirrhosis. Also widely used as feed additives to improve feed quality, improve the utilization of the native protein and promote animal growth. Such as DL-methionine can increase egg production of chickens, pigs make weight gain, more milk cows and so on. Adverse reaction: hepatic coma hanged.
  • Nutritional supplements. One of the essential amino acids of the human body. Because the price is higher than DL-methionine and the results are equal, so commonly used DL-methionine.
  • For biochemical studies and nutritional supplements, and as adjunctive treatment for pneumonia, liver cirrhosis and fatty liver.
Spectrum DetailBack Directory
[Spectrum Detail]

L-Methionine(63-68-3) IR2
L-Methionine(63-68-3) MS
L-Methionine(63-68-3) 13C NMR
L-Methionine(63-68-3) IR1
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

L-Methionine, 98+%(63-68-3)
[Alfa Aesar]

L-Methionine, 98+%(63-68-3)
[Sigma Aldrich]


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