| Identification | Back Directory | [Name]
Granatcin-A | [CAS]
19879-06-2 | [Synonyms]
WR-141
granaticin
Litmomycin
Granatcin-A
Granaticin A
Granatomycin C
Antibiotic WR-141
(3aS,15R)-3,3aβ,5,8,11,13bβ-Hexahydro-7,8,12,15-tetrahydroxy-5β,9β-dimethyl-8α,11α-ethanofuro[2,3-e]naphtho[2,3-c:6,7-c']dipyran-2,6,13(9H)-trione
8,11-Ethanofuro[2,3-e]naphtho[2,3-c:6,7-c']dipyran-2,6,13(9H)-trione, 3,3a,5,8,11,13b-hexahydro-7,8,12,15-tetrahydroxy-5,9-dimethyl-, (3aS,5S,8S,9R,11R,13bS,15R)- | [Molecular Formula]
C22H20O10 | [MOL File]
19879-06-2.mol | [Molecular Weight]
444.39 |
| Chemical Properties | Back Directory | [Melting point ]
211-213° (dec) | [Boiling point ]
474.41°C (rough estimate) | [density ]
1.3550 (rough estimate) | [refractive index ]
1.5376 (estimate) | [pka]
6.56±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Granaticin A inhibits the initial stage of RNA biosynthesis, has anti-Gram-positive bacteria, Mycobacterium (weak) and Vaginal trichomonas activity, but also can inhibit tumor cells[1]. | [References]
[1] Qianqian Lv, et al. Sekgranaticin, a SEK34b-Granaticin Hybrid Polyketide from Streptomyces sp. 166. J Org Chem. 2019 Jul 19;84(14):9087-9092. |
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