| Identification | Back Directory | [Name]
MJ 33 | [CAS]
199106-13-3 | [Synonyms]
MJ33-OH
Phosphoric acid, mono[1-[(hexadecyloxy)methyl]-2-(2,2,2-trifluoroethoxy)ethyl] mono(hydroxymethyl) ester | [Molecular Formula]
C22H44F3O7P | [MDL Number]
MFCD03787978 | [MOL File]
199106-13-3.mol | [Molecular Weight]
508.55 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: ≥5mg/mL (warmed at 60 °C) | [form ]
solid
| [color ]
white to beige | [Water Solubility ]
H2O: ≥5mg/mL (warmed at 60 °C) | [InChI]
1S/C22H44F3O6P.Li/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29-18-21(31-32(26,27)28-2)19-30-20-22(23,24)25;/h21H,3-20H2,1-2H3,(H,26,27);/q;+1/p-1 | [InChIKey]
GDLMLQJISATCEL-UHFFFAOYSA-M | [SMILES]
CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(OC)([O-])=O.[Li+] |
| Hazard Information | Back Directory | [Uses]
MJ33 lithium salt has been used as a peroxiredoxin VI (Prdx6) inhibitor:
- to study its specific Prdx6 peroxidase activity in vitro and in breast cancer cell line (MCF-7) cell lysates
- to study its effects on a mouse model of acute lung injury associated with exposure to hyperoxia
- to study its potential use as a therapeutic agent
| [Biochem/physiol Actions]
MJ33 acts as a non-toxic and potent inhibitor of agonist-induced activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase type 2 (NOX2). It also prevents lung injuries associated with lung inflammation in mice. MJ33 is a fluorinated lipid analog, which blocks the enzyme by mimicking the transition state of the substrate. | [in vivo]
MJ33 (0.5 μM/kg; by tail vein, at 24 h before MCAO) significantly blocks the increase IL-1β, IL-17 and IL-23 in rats stimulated by Prdx6 siRNA treatment[2].
Compared with the Prdx6 siRNA group, combined exposure to Prdx6 siRNA and MJ33 significantly downregulates the mRNA and protein expression of NF-κB, iNOS and COX-2[2]. |
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