| Identification | Back Directory | [Name]
endo-BCN-PEG2-acid | [CAS]
1993134-72-7 | [Synonyms]
endo-BCN-PEG2-acid
4,7,12-Trioxa-10-azatridecanoic acid, 13-(1R,8S)-bicyclo[6.1.0]non-4-yn-9-yl-11-oxo-, rel- | [Molecular Formula]
C18H27NO6 | [MDL Number]
MFCD31692189 | [MOL File]
1993134-72-7.mol | [Molecular Weight]
353.41 |
| Chemical Properties | Back Directory | [Boiling point ]
546.4±40.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C, sealed storage, away from moisture | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
endo-BCN-PEG2-acid is a PEG linker containing a BCN group and a terminal carboxylic acid. The BCN group can react with azide-tagged biomolecules. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
endo-BCN-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. endo-BCN-PEG2-acid is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] Sano K, et al. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. DOI:10.1021/bc400050k |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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