| Identification | Back Directory | [Name]
PD 166793 | [CAS]
199850-67-4 | [Synonyms]
PD 166793
PD 166793 USP/EP/BP
MMP-2/MMP-3 Inhibitor
N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine
L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-
(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid
(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci
(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid | [Molecular Formula]
C17H18BrNO4S | [MDL Number]
MFCD09038565 | [MOL File]
199850-67-4.mol | [Molecular Weight]
412.3 |
| Chemical Properties | Back Directory | [Melting point ]
192-193℃ | [density ]
1.457 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml | [form ]
A crystalline solid | [color ]
White to pink | [InChI]
1S/C17H18BrNO4S/c1-11(2)16(17(20)21)19-24(22,23)15-9-5-13(6-10-15)12-3-7-14(18)8-4-12/h3-11,16,19H,1-2H3,(H,20,21)/t16-/m0/s1 | [InChIKey]
GJOCABIDMCKCEG-INIZCTEOSA-N | [SMILES]
[S](=O)(=O)(N[C@@H](C(C)C)C(=O)O)c1ccc(cc1)c2ccc(cc2)Br |
| Hazard Information | Back Directory | [Uses]
PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system. | [General Description]
A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes. | [Biological Activity]
Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure. | [Biochem/physiol Actions]
Cell permeable: yes | [storage]
Desiccate at +4°C |
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