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391210-10-9

391210-10-9 Structure

391210-10-9 Structure
IdentificationBack Directory
[Name]

PD 0325901
[CAS]

391210-10-9
[Synonyms]

PD325901
PD 0325901
PD-0235901
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]be
(R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide
N-[(R)-2,3-Dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodo-phenylaMino)-benzaMide
N-[(2R)-2,3-DIHYDROXYPROPOXY]-3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-BENZAMIDE
PD 0325901 N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide PD0325901
[EINECS(EC#)]

687-152-7
[Molecular Formula]

C16H14F3IN2O4
[MDL Number]

MFCD08435926
[MOL File]

391210-10-9.mol
[Molecular Weight]

482.191
Chemical PropertiesBack Directory
[Melting point ]

112-114°C
[density ]

1.817±0.06 g/cm3(Predicted)
[storage temp. ]

Store at-20°C
[solubility ]

DMSO: soluble20mg/mL, clear
[form ]

White to off-white solid
[pka]

13.45±0.20(Predicted)
[color ]

white to off-white
[optical activity]

[α]/D -1.8 to -3.5°, c = 1 mg/mL in methanol
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
[InChIKey]

SUDAHWBOROXANE-SECBINFHSA-N
Hazard InformationBack Directory
[Chemical Properties]

White to Off-White Solid
[Usage]

The mitogenic extracellular kinase 1/2 (MEK1/2) inhibitor
[Description]

PD 325901 (391210-10-9) is a selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM).1 Inhibits growth and/or proliferation of a variety of cancer cells.2 Enhances self-renewal of embryonic stem cells.3 In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells.4 In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells.5
[Uses]

PD 0325901 has been used as an inhibitor in extracellular signal-regulated kinase (ERK) inhibition assay in primed induced pluripotent stem cells, RKO colorectal cancer cell line and human embryonic stem cells(hESCs).
[Uses]

The mitogenic extracellular kinase 1/2 (MEK1/2) inhibitor
[Definition]

ChEBI: A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).
[Biochem/physiol Actions]

PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.
[storage]

-20°C
[References]

1) Sebolt-Leopold et al. (2004), The biological profile of PD0325901: A second generation analog of CI-1040 with improved pharmaceutical potential; Proc. Amer. Assoc. Cancer Res., 45 925 2) Ciuffreda et al. (2009), Growth-inhibitor and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations; Neoplasia, 11 720 3) Ai et al. (2016), Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901; Stem Cells Int., 2016 1792573 4) Li et al. (2016), MEK inhibitor PD0325901 and vitamin C synergistically induce hypomethylation of mouse embryonic stem cells; Oncotarget, 7 39730 5) Li et al. (2009), Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors; Cell Stem Cell, 4 16
Safety DataBack Directory
[Hazard Codes ]

T,N
[Risk Statements ]

25-48-50
[Safety Statements ]

22-36/37/39-61
[RIDADR ]

UN 2811 6.1 / PGIII
[WGK Germany ]

3
[HazardClass ]

IRRITANT
[HS Code ]

29242990
Spectrum DetailBack Directory
[Spectrum Detail]

PD 0325901(391210-10-9)1HNMR
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