| Chemical Properties | Back Directory | [Boiling point ]
679.4±55.0 °C(Predicted) | [density ]
1.327±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.16±0.25(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Description]
HTH-01-091 is a selective maternal embryonic leucine zipper kinase (MELK) inhibitor. HTH-01-091 provides a general framework for preclinical target validation. | [Uses]
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research[1]. | [IC 50]
DYRK4: 41.8 nM (IC50); RIPK2; PIM1: 60.6 nM (IC50); mTOR: 632 nM (IC50); CDK7: 1230 nM (IC50); PIM2; PIM3 | [References]
[1] Huang HT, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693. DOI:10.7554/eLife.26693 |
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