| Identification | Back Directory | [Name]
9H-Pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine, 9-methyl-2,4-di-1-pyrrolidinyl-, hydrochloride (1:1) | [CAS]
200266-76-8 | [Synonyms]
9H-Pyrido[3',4':4,5]pyrrolo[2,3-d]pyrimidine, 9-methyl-2,4-di-1-pyrrolidinyl-, hydrochloride (1:1) | [Molecular Formula]
C18H23ClN6 | [MOL File]
200266-76-8.mol | [Molecular Weight]
358.87 |
| Hazard Information | Back Directory | [Uses]
PNU-107484A is a GABAA receptor ligand that exhibits target activity mechanisms dependent on α isoforms. In the α1β2γ2 subtype, PNU-107484A acts as a positive allosteric modulator, enhancing GABA-induced Cl- currents, while it inhibits the currents in the α3β2γ2 and α6β2γ2 subtypes. The half-maximal concentrations for the α1β2γ2, α3β2γ2, and α6β2γ2 subtypes are 3.1, 4.2, and 3.5 μM, respectively. PNU-107484A can be used as a probe to investigate the physiological roles of different α isoform subtypes[1]. | [References]
[1] Im HK, et al. PNU-107484A with alpha isoform-dependent functional changes in alpha(x)beta2gamma2 subtypes of rat recombinant GABA(A) receptors. Br J Pharmacol. 1997 Nov;122(5):821-4. DOI:10.1038/sj.bjp.0701450 |
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