| Identification | Back Directory | [Name]
1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)- | [CAS]
2004677-13-6 | [Synonyms]
GS-9688
Selgantolimod
(2S)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol
1-Hexanol, 2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methyl-, (2R)- | [Molecular Formula]
C14H20FN5O | [MDL Number]
MFCD32693858 | [MOL File]
2004677-13-6.mol | [Molecular Weight]
293.34 |
| Chemical Properties | Back Directory | [Boiling point ]
535.1±60.0 °C(Predicted) | [density ]
1.299±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
14.86±0.10(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C14H20FN5O/c1-3-4-5-14(2,8-21)20-12-11-10(18-13(16)19-12)6-9(15)7-17-11/h6-7,21H,3-5,8H2,1-2H3,(H3,16,18,19,20)/t14-/m1/s1 | [InChIKey]
HTCJUBZBSJQWBW-CQSZACIVSA-N | [SMILES]
C(O)[C@@](NC1N=C(N)N=C2C=C(F)C=NC2=1)(C)CCCC |
| Hazard Information | Back Directory | [Uses]
Selgantolimod (GS-9688) is an orally active, potent and selective toll-like receptor 8 (TLR8) agonist for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection[1][2][3]. | [in vivo]
Once-weekly dosing of oral Selgantolimod induces dose-dependent increases in serum IL-12 and IL-1 receptor antagonist (IL-1RA) in cynomolgus monkeys, and leads to functional cure in the woodchuck model of chronic HBV[1]. | [IC 50]
TLR8; HBV | [References]
[1] Jules Levin. Efficacy and Safety of Oral TLR8 Agonist Selgantolimod in Virally Suppressed Adult Patients With Chronic Hepatitis B: a Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study. 2019 Nov 8-12.
[2] Benjamin Ryan. Selgantolimod Shows Promise as Treatment for Hepatitis B. November 18, 2019.
[3] Romas Geleziunas, et al. Modulators of toll-like receptors for the treatment of hiv. US20170071944A1. |
|
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|