ChemicalBook--->CAS DataBase List--->200801-70-3

200801-70-3

200801-70-3 Structure

200801-70-3 Structure
IdentificationBack Directory
[Name]

rac 5-Hydroxymethyl Tolterodine, 90% by HPLC
[CAS]

200801-70-3
[Synonyms]

Fesoterodine IMpurity A
rac 5-Hydroxymethyl Tolterodine
racemic 5-hydroxymethyl tolterodine
Tolterodine 5-HydroxyMethyl Analog RaceMate
rac 5-Hydroxymethyl Tolterodine, 90% by HPLC
Tolterodine 5-Hydroxymethyl (racemate, as HCl salt)
2-(3-(diisopropylaMino)-1-phenylpropyl)-4-(hydroxyMethyl)phenol
3-[3-[Bis(1-Methylethyl)aMino]-1-phenylpropyl]-4-hydroxybenzeneMethanol
BenzeneMethanol, 3-[3-[bis(1-Methylethyl)aMino]-1-phenylpropyl]-4-hydroxy-
[Molecular Formula]

C22H31NO2
[MDL Number]

MFCD09840742
[MOL File]

200801-70-3.mol
[Molecular Weight]

341.487
Chemical PropertiesBack Directory
[Appearance]

Light Beige Solid
[Melting point ]

52-53°C
[Boiling point ]

490.7±45.0 °C(Predicted)
[density ]

1.060±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C Freezer
[solubility ]

Acetonitrile (Slightly), Chloroform (Slightly)
[form ]

Solid
[pka]

9.61±0.48(Predicted)
[color ]

Off White to Pale Yellow
Hazard InformationBack Directory
[Chemical Properties]

Light Beige Solid
[Uses]

A metabolite of Tolterodine (T535800), a muscarinic receptor antagonist used in the treatment of urinary incontinence. Also, a degradation product of Fesoterodine (F321300) formed under stress condit ions in tablet dosage forms.
[Uses]

A metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.
[in vivo]

(Rac)-5-Hydroxymethyl Tolterodine (5-HMT; 0.88 μmol/kg; i.v.) treatment shows the binding activity of (Rac)-5-Hydroxymethyl Tolterodine to muscarinic receptors is significantly observed in all tissues, except cerebral cortex, with a longer duration in bladder[3].

[IC 50]

mAChR1; mAChR3; mAChR4; mAChR5
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