| Identification | Back Directory | [Name]
1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodiuM salt) | [CAS]
200880-42-8 | [Synonyms]
18:0 PG
DSPG Sodium Salt
L-α-Phosphatidyl-DL-glycerol, distearoyl
1,2-Distearoyl-sn-glycero-3-PG (sodium salt)
1,2-Distearoyl-sn-glycero-3-phosphorylglycerol sodium salt
1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodiuM salt)
Sodium (2R)-2,3-Bis(stearoyloxy)propyl 2,3-Dihydroxypropyl Phosphate
1,2-Dioctadecanoyl-sn-glycero-3-phospho-(1′-rac-glycerol) sodium salt
1,2-distearoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)(DSPG)
sodium [(2R)-2,3-bis(1-oxooctadecoxy)propyl] 2,3-dihydroxypropyl phosphate
1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHO-(1'-RAC-GLYCEROL) (SODIUM SALT);18:0 PG;DSPG;PG(18:0/18:0)
Octadecanoic acid (1R)-1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester monosodium salt
1,2-Dioctadecanoyl-sn-glycero-3-phospho-(1′-rac-glycerol) sodium salt, 1,2-Distearoyl-sn-glycero-3-phosphoglycerol, L -α-Phosphatidyl-DL-glycerol, distearoyl, DSPG-Na, Octadecanoic acid (1R)-1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-1,2-eth | [Molecular Formula]
C81H159Na2O16P | [MDL Number]
MFCD00077290 | [MOL File]
200880-42-8.mol | [Molecular Weight]
1466.07 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Chloroform:Methanol:Water = 2:1:0.1 (Very Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic | [InChIKey]
YNQYZBDRJZVSJE-QTOMIGAPSA-M | [SMILES]
[Na+].[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC)OCC(O)CO |
| Hazard Information | Back Directory | [Description]
DSPG, also known as 1,2-Distearoyl-sn-glycero-3-phosphoglycerol, is a phospholipid molecule with phosphate polar head connected to two non-polar lipid (stearic acid) by a glycerol molecule. In water, the molecule can orient itself into lipid bilayer and can be used for drug encapsulation, such as drug loaded liposomes or nanoparticles. | [Uses]
1,2-Distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) Sodium Salt is used to prepare polyethyleneglycol-modified liposomal doxorubicin for therapies against drug resistant tumors. It is also used in the PEGylated liposomal drug formulation of the anti-cancer agent oxaliplatin. | [in vivo]
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (DSPG) sodium can be used to prepare negatively charged nanoliposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium nanoliposome formulations correct dyslipidaemia and inhibit the progression of atherosclerosis in rabbits fed a high cholesterol diet[1]. |
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