| Identification | Back Directory | [Name]
5-cholesten-3-ol 6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)aMino]caproate | [CAS]
201731-19-3 | [Synonyms]
NBD-6 Cholesterol
3-hexanoyl-NBD Cholesterol (3-C6-NBD Cholesterol)
5-cholesten-3-ol 6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)aMino]caproate
5-cholesten-3β-ol 6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]caproate
Cholest-5-en-3-ol (3β)-, 3-[6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanoate]
5-CHOLESTEN-3-OL 6-[(7-NITRO-2-1,3-BENZOXADIAZOL-4-YL)AMINO]CAPROATE;NBD-6 CHOLESTEROL | [Molecular Formula]
C39H58N4O5 | [MOL File]
201731-19-3.mol | [Molecular Weight]
662.9 |
| Chemical Properties | Back Directory | [Boiling point ]
736.3±70.0 °C(Predicted) | [density ]
1.16±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: 1 mg/ml; DMSO: 0.25 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
-3.75±0.45(Predicted) |
| Hazard Information | Back Directory | [Uses]
3-hexanoyl-NBD Cholesterol is a fluorescently-tagged cholesterol derivative with hydrophilic NBD fluorophore attached to carbon 3, at the hydrophilic end of cholesterol, separated by a 6-carbon spacer. This allows the cholesterol to orient in membrane bilayers while the fluorescent tag is presented outside the bilayer. This should model the behavior of cholesterol in membranes better than the previously-used 25-NBD cholesterol, which positions NBD directly on the 25th carbon of cholesterol at the hydrophobic terminus. Fluorescently-tagged lipids are used to study their interactions with proteins, their utilization by cells, and liposomes, and for the development of assays for lipid metabolism. | [Biological Activity]
Cholesterol is produced from acetyl-CoA by a complex multistep mevalonate pathway. In mammalsliver is the main site of de novo cholesterol synthesis contributing to almost 80% of total cholesterol synthesis. Cholesterol and its metabolitesalong with its precursorsplay important roles in cellular membrane physiology. They also have roles in reproductive biologydietary nutrient absorptionstress responsessalt and water balance and calcium metabolism. |
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Energy Chemical
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Creative Enzymes
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