| Identification | Back Directory | [Name]
DesfluoroMethyl Fluticasone Propionate Disulfide | [CAS]
201812-64-8 | [Synonyms]
Fluticasone EP Imp H
Propionate Impurity H
Fluticasone Impurity 9
Fluticasone Disulphane Impurity
Fluticasone Propionate EP Impurity H
Fluticasone Propionate Disulfide Dimer Impurity
DesfluoroMethyl Fluticasone Propionate Disulfide
Fluticasone Impurity 8(Fluticasone EP Impurity H)
Androsta-1,4-dien-3-one, 17,17'- (dithiodicarbonyl)bis[6,9- difluoro-11-hydroxy-16-Methyl-17-(1-oxopropoxy)-, (6α,11β, 16α,17α)-(6'α,11'β,16'α,17'α)-
Fluticasone Propionate EP Impurity H/Fluticasone Disulphane Impurity/Desfluoromethyl Fluticasone Propionate Disulfide/17,17′-(Disulphanediyldicarbonyl)bis(6α,9-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-dien-17α-yl) dipropanoate | [Molecular Formula]
C48H58F4O10S2 | [MDL Number]
MFCD21363598 | [MOL File]
201812-64-8.mol | [Molecular Weight]
935.092 |
| Chemical Properties | Back Directory | [Melting point ]
>200°C | [Boiling point ]
905.0±75.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
Solid | [pka]
12.20±0.70(Predicted) | [color ]
Off-White to Light Yellow |
| Hazard Information | Back Directory | [Uses]
Desfluoromethyl Fluticasone Propionate Disulfide is the disulfide conjugated dimer of Fluticasone Propionate (F599500), a derivative of flumethasone and an anti-inflammatory agent. | [Synthesis]
This is an impurity formed during the synthesis of Fluticasone Propionate. Its formation involves key steps: oxidative cleavage of the C-17 hydroxymethyl group in flumetasone, activation of the resulting acid and reaction with H₂S to give a thiocarboxylic |
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