| Identification | Back Directory | [Name]
2-Azetidineacetic acid, 1-[[(2-methylphenyl)amino]carbonyl]-4-oxo- | [CAS]
2023788-32-9 | [Synonyms]
Integrin modulator 1
2-Azetidineacetic acid, 1-[[(2-methylphenyl)amino]carbonyl]-4-oxo- | [Molecular Formula]
C13H14N2O4 | [MDL Number]
MFCD32868990 | [MOL File]
2023788-32-9.mol | [Molecular Weight]
262.26 |
| Chemical Properties | Back Directory | [density ]
1.413±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [solubility ]
DMSO: 100 mg/mL (381.30 mM) | [form ]
Solid | [pka]
4.20±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1]. | [IC 50]
α4β1: 9.8 nM (IC50) | [References]
[1] Baiula M, et, al. New β-Lactam Derivatives Modulate Cell Adhesion and Signaling Mediated by RGD-Binding and Leukocyte Integrins. J Med Chem. 2016 Nov 10;59(21):9721-9742. DOI:10.1021/acs.jmedchem.6b00576 |
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