| Identification | Back Directory | [Name]
α-Amyrenone | [CAS]
20248-08-2 | [Synonyms]
α-Amyrenone
δ-Amyrenane
δ-Amyrenone
Delta-Amyrone
13(18)-Oleanen-3-one
Olean-13(18)-en-3-one
5α-Olean-13(18)-en-3-one
(6aR,6bS,8aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-2,4a,5,6,7,8,9,10,12,13,14,14a-dodecahydro-1H-picen-3-one | [Molecular Formula]
C30H48O | [MDL Number]
MFCD20260471 | [MOL File]
20248-08-2.mol | [Molecular Weight]
424.7 |
| Chemical Properties | Back Directory | [Melting point ]
198-201 °C | [Boiling point ]
488.8±44.0 °C(Predicted) | [density ]
1.01±0.1 g/cm3(Predicted) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
δ-Amyrenone (Delta-Amyrone) is a pentacyclic triterpene compound from S. lineare, with anti-inflammatory effects[1]. | [in vivo]
δ-Amyrone (4 mg/kg and 8 mg/kg; i.p.) inhibits lipopolysaccharide-induced inflammatory cytokines and protects against endotoxic shock in mice[1].
| [References]
[1] Niu X, et al.δ-Amyrone, a specific inhibitor of cyclooxygenase-2, exhibits anti-inflammatory effects in vitro and in vivo of mice. Int Immunopharmacol. 2014 Jul;21(1):112-8. DOI:10.1016/j.intimp.2014.04.019
[2] Niu X, et al.δ-Amyrone inhibits lipopolysaccharide-induced inflammatory cytokines and protects against endotoxic shock in mice. Chem Biol Interact. 2015 Oct 5;240:354-61. DOI:10.1016/j.cbi.2015.07.007 |
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