| Identification | Back Directory | [Name]
H-ARG-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 | [CAS]
202801-92-1 | [Synonyms]
Rat orexin B
OREXIN B (MOUSE)
HYPOCRETIN-B, MOUSE
OREXIN-B (RAT, HUMAN)
OREXIN B (MOUSE, RAT)
OREXIN B (RAT, MOUSE)
Hypocretin-2 (Mouse, rat)
OREXINS OREXIN B RAT, MOUSE
RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2
Orexin B (rat, mouse), ≥97% (HPLC)
Orexin B (Mouse, rat)
Hypocretin-2 (Mouse, rat)
ARG-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
ARG-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG- LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
H-ARG-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2
REF DUPL: H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
H-ARG-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 USP/EP/BP
L-Methioninamide, L-arginyl-L-prolylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-asparaginylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl- (9CI) | [Molecular Formula]
C126H215N45O34S | [MDL Number]
MFCD01635376 | [MOL File]
202801-92-1.mol | [Molecular Weight]
2936.4 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble in 1% acetic acid at 1mg/ml | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Soluble in water (1 mg/ml) | [Sequence]
Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
| Hazard Information | Back Directory | [Uses]
Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. | [Biological Activity]
Orexin B (mouse) is an endogenous agonist of the Orexin receptor with Ki values of 420 and 36 nM for OX1 and OX2, respectively. | [in vivo]
Orexin-B modulates the activity of rod bipolar cells (RBCs) located in the outer retina of rat. Intravitreal injection of orexin-B increased the amplitude of the scotopic electroretinographic b-wave, a reflection of RBC activity, recorded in vivo[4]. | [target]
Ki: 420 nM (OX1), 36 nM (OX2) | [IC 50]
OX2 Receptor | [storage]
-20°C | [References]
[1] Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. DOI:10.1093/bja/83.5.695
[2] Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. DOI:10.1016/s0092-8674(00)80949-6
[3] Ziolkowska A, et al. Orexin B inhibits proliferation and stimulates specialized function of cultured rat calvarial osteoblast-like cells. Int J Mol Med. 2008;22(6):749-755. PMID:19020772
[4] Zhang G, et al. Orexin-B modulates synaptic transmission of rod bipolar cells in rat retina. Neuropharmacology. 2018;133:38-50. DOI:10.1016/j.neuropharm.2018.01.007 |
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