| Identification | Back Directory | [Name]
MRZ 2-514 | [CAS]
202808-11-5 | [Synonyms]
MRZ 2-514
Pyridazino[4,5-b]quinoline-1,4-dione, 8-bromo-2,3-dihydro-, 5-oxide | [Molecular Formula]
C11H6BrN3O3 | [MDL Number]
MFCD31382150 | [MOL File]
202808-11-5.mol | [Molecular Weight]
308.09 |
| Chemical Properties | Back Directory | [density ]
2.07±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
9.37±0.20(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM. | [Biological Activity]
MRZ 2-514 is an NMDA receptor (glycineB) antagonist with a Ki of 33 μM. | [in vitro]
MRZ 2-514 has IC 50 values against peak AMPA-induced currents of 72.7 μM. < /div> | [in vivo]
MRZ 2/514 has anticonvulsive action in the MES model in mice, and the effect is prolonged by probenecid. | [target]
| [IC 50]
NMDA Receptor | [storage]
Store at -20°C | [References]
[1] Parsons CG, et al. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Journal of Pharmacology and Experimental Therapeutics (1997), 283(3), 1264-1275 PMID:9400002 |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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