| Identification | Back Directory | [Name]
METHYL 3,4,5-TRIMETHOXYCINNAMATE | [CAS]
20329-96-8 | [Synonyms]
5-TRIMETHOXYCINNAMATE
METHYL TRIMETHOXYCINNAMATE
Methyl 3,4,5-TriMethyl cinnaMate
METHYL 3,4,5-TRIMETHOXYCINNAMATE
Methyl (E)-3,4,5-trimethoxycinnamate
Methyl trans-3,4,5-trimethoxycinnamate
Methyl 3,4,5-trimethoxy-trans-cinnamate
Methyl trans-3-(3,4,5-trimethoxyphenyl)acrylate
2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, methyl ester, (2E)-
Methyl trans-3-(3,4,5-trimethoxyphenyl)prop-2-enoate, Methyl (2E)-3-(3,4,5-trimethoxyphenyl)acrylate | [Molecular Formula]
C13H16O5 | [MDL Number]
MFCD03614740 | [MOL File]
20329-96-8.mol | [Molecular Weight]
252.26 |
| Chemical Properties | Back Directory | [Melting point ]
91-92℃ | [Boiling point ]
371℃ | [density ]
1.134 | [Fp ]
164℃ | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes[1][2]. | [Definition]
ChEBI: Methyl-3,4,5-trimethoxy cinnamate is an alkyl cinnamate obtained by the formal condensation of the carboxy group of 3,4,5-trimethoxycinnamic acid with methanol. It is a member of methoxybenzenes and an alkyl cinnamate. | [References]
[1] Olajide OA, et al. Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. Inflammopharmacology. 2020 Oct;28(5):1315-1326. DOI:10.1007/s10787-020-00720-8
[2] Zhao Z, et al. Potential antiarrhythmic effect of methyl 3,4,5-trimethoxycinnamate, a bioactive substance from roots of polygalae radix: suppression of triggered activities in rabbit myocytes. Biol Pharm Bull. 2013;36(2):238-44. DOI:10.1248/bpb.b12-00654 |
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